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Midwest225 facilities

Drug & Alcohol Rehab Centers in Missouri

Missouri's gateway cities of St. Louis and Kansas City offer extensive treatment networks serving the Midwest region. The state has developed strong prescription monitoring and expanded treatment access.

Serving Kansas City, Saint Louis, Springfield, Columbia and communities throughout Missouri.

Updated: December 19, 2025
Sources:
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Harry S Truman Memorial
+9 photos

Harry S Truman Memorial

Veterans Hospital

Columbia, MO 65201
573-814-6000 x6300

The Harry S Truman Memorial, situated in Columbia, MO, is a full-service rehabilitation center that provides specialized treatment for detoxification, substance use, and co-occurring serious mental health issues in adults, as well as emotional challenges in children. Their offerings include hospital inpatient detoxification, round-the-clock hospital care, and long-term residential support. The center employs a variety of therapeutic approaches, including 12-step facilitation, anger management, and brief intervention therapies. They also have unique programs designed specifically for individuals who have experienced intimate partner violence, domestic violence, sexual abuse, and trauma. Catering to adults and young adults of all genders, the facility is committed to delivering high-quality, personalized care that supports each individual’s recovery journey.

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Higher Ground Recovery Center
+9 photos

Higher Ground Recovery Center

Springfield, MO 65803
417-869-0700

Higher Ground Recovery Center, situated in Springfield, MO, provides a broad spectrum of substance use treatment programs designed to address the unique needs of each client. The facility offers various levels of care, including intensive outpatient treatment, outpatient services, and regular outpatient options. Utilizing evidence-based methods, the center incorporates 12-step facilitation, anger management, and brief intervention strategies. Understanding that different populations may require specific attention, Higher Ground Recovery Center has developed specialized programs for adult men, adult women, and individuals who have faced intimate partner violence. They are committed to serving both adults and young adults of all genders, ensuring a focus on high-quality care and personalized support to foster long-term recovery.

Substance use treatmentTransitional housing, halfway house, or sober home
INSynergy Treatment Program
+9 photos

INSynergy Treatment Program

Saint Louis, MO 63141
314-649-7867

The INSynergy Treatment Program, located in Saint Louis, MO, provides a wide variety of outpatient services aimed at detoxification, treating substance use disorders, and addressing co-occurring mental health issues in adults, alongside emotional challenges in children. The facility offers tailored outpatient detoxification, as well as methadone and buprenorphine treatments. Focusing on anger management, brief interventions, and cognitive behavioral therapy, INSynergy is equipped to support adult men and women, including those grappling with both mental health and substance use disorders. Committed to quality care, the program serves individuals of all ages and genders, including adults, children, and adolescents, all within a nurturing and inclusive atmosphere.

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Mark Twain Behavioral Health
+9 photos

Mark Twain Behavioral Health

Hannibal, MO 63401
573-221-2120

Located in Hannibal, MO, Mark Twain Behavioral Health provides a wide range of outpatient rehabilitation services for those struggling with substance use disorders as well as co-occurring mental health issues. Their specialized programs are designed for adults facing serious mental health challenges or emotional disturbances, ensuring that each client receives a personalized treatment plan. This may include options like anger management, cognitive behavioral therapy, and brief interventions. As part of their offerings, the facility provides outpatient treatment options that include methadone, buprenorphine, or naltrexone, focusing on delivering high-quality care for adult men, women, and adolescents. With a strong commitment to individualized care, Mark Twain Behavioral Health fosters a supportive atmosphere for clients of all genders, guiding them along their path to recovery.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Mark Twain Behavioral Health
+9 photos

Mark Twain Behavioral Health

Bowling Green, MO 63334
573-248-1196

Situated in Bowling Green, MO, Mark Twain Behavioral Health delivers a wide range of addiction treatment services. The center specializes in outpatient detoxification and substance use treatment, along with offering distinct programs designed for adolescents, adult men, and adult women. Their treatment strategies incorporate 12-step facilitation, anger management, and brief intervention, ensuring support for both adults and young adults of all genders. Renowned for its high-quality care and customized programs, Mark Twain Behavioral Health stands out as a leading option for those in search of effective and personalized addiction treatment in the area.

DetoxificationSubstance use treatment
Mark Twain Behavioral Health
+3 photos

Mark Twain Behavioral Health

Hannibal, MO 63401
573-248-1196

Located in Hannibal, MO, Mark Twain Behavioral Health offers a wide array of outpatient services designed for those in recovery from substance use disorders as well as those facing co-occurring mental health challenges. The facility specializes in treatment programs catering to adults with significant mental health issues and children grappling with serious emotional disturbances. Emphasizing 12-step facilitation, anger management, and brief interventions, the center customizes its treatment strategies to address the specific needs of each individual. It also features special programs aimed at adolescents and provides tailored care for adult men and women, ensuring that various populations receive the focused attention they deserve. Mark Twain Behavioral Health is committed to delivering high-quality, gender-specific treatment in a nurturing and supportive setting for both adults and young adults.

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Gibson Recovery Center Inc
+2 photos

Gibson Recovery Center Inc

Cape Girardeau, MO 63703
573-332-0416 x159

Gibson Recovery Center Inc, located in Cape Girardeau, MO, specializes in substance use treatment for adult women who are also facing mental health challenges. This facility offers a range of services, including intensive outpatient treatment, outpatient day treatment, and trauma-focused counseling. They serve adults, seniors, and young adults, particularly concentrating on individuals with co-occurring disorders and those navigating the criminal justice system. With a strong commitment to providing female-specific care, Gibson Recovery Center Inc is dedicated to delivering rehabilitation services that are thoughtfully tailored to meet the unique needs of each client.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Gibson Recovery Center Inc
+2 photos

Gibson Recovery Center Inc

Cape Girardeau, MO 63703
573-332-0416 x105

Situated in Cape Girardeau, MO, Gibson Recovery Center Inc delivers a wide array of addiction treatment services tailored for both adults and young adults. The center specializes in detoxification, intensive outpatient therapy, and outpatient day treatment, emphasizing counseling for substance use disorders, trauma-informed therapy, and telemedicine services. They also have special programs designed for adult men, individuals facing co-occurring mental health and substance use issues, as well as forensic clients. With a strong focus on providing quality care and crafting personalized treatment plans, this facility is open to all individuals—both male and female—who are on their journey to recovery from addiction and related conditions.

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Gibson Recovery Center Inc
+2 photos

Gibson Recovery Center Inc

Marble Hill, MO 63764
573-332-0416 x140

Situated in Marble Hill, MO, Gibson Recovery Center Inc provides thorough substance use treatment tailored for both adults and young adults. This facility offers a range of outpatient services, including treatments with methadone, buprenorphine, or naltrexone. The center places a strong emphasis on counseling for substance use disorders as well as trauma-related issues, and it also offers telemedicine and telehealth therapy for added convenience. Understanding the complexities that come with co-occurring mental health conditions, Gibson Recovery Center Inc has developed specialized programs for both adult men and women. Committed to delivering high-quality care, the center effectively supports individuals embarking on the journey to recovery from substance use disorders and co-occurring challenges, utilizing various therapeutic strategies to meet diverse client needs.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Heartland Center for Behavioral Change
+1 photos

Heartland Center for Behavioral Change

Kansas City Outpatient Clinic

Kansas City, MO 64108
816-214-9107

Located in Kansas City, MO, the Heartland Center for Behavioral Change provides a wide variety of treatment services designed for both adults and young adults facing challenges related to substance use and co-occurring mental health issues. Here, you'll find options such as intensive outpatient treatment, outpatient care, and day treatment programs. The center specializes in techniques including anger management, cognitive behavioral therapy, and the Matrix Model, all customized to meet the unique needs of each individual. Additionally, specific programs are available for adult men, adult women, and those who have experienced trauma. Heartland Center for Behavioral Change is dedicated to delivering high-quality, personalized care, ensuring that every client receives effective treatment tailored to their needs.

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Mark Twain Behavioral Health
+1 photos

Mark Twain Behavioral Health

Mexico, MO 65265
573-248-1196

Mark Twain Behavioral Health, located in Mexico, MO, provides targeted substance use treatment for both adults and young adults via outpatient and regular outpatient programs. The facility emphasizes 12-step facilitation, anger management, and brief intervention strategies to create personalized treatment plans that cater to each individual's needs. They also offer specialized programs for clients involved with the criminal justice or forensic systems. Welcoming both men and women, the center fosters a comprehensive and supportive setting for anyone on their recovery journey. With a strong commitment to delivering quality care, Mark Twain Behavioral Health stands out as an excellent option for those looking to tackle substance use challenges in a structured and effective way.

Substance use treatment
Mark Twain Behavioral Health
+1 photos

Mark Twain Behavioral Health

Kirksville, MO 63501
660-665-4612

Located in Kirksville, MO, Mark Twain Behavioral Health provides outpatient treatment for substance use and specialized support for individuals facing both substance use and significant mental health challenges. Their programs are designed for adults, children, and adolescents, and include services such as anger management, brief interventions, and cognitive behavioral therapy. The center places great emphasis on helping those with co-occurring disorders, offering personalized treatment plans for both males and females. At Mark Twain Behavioral Health, clients can expect to receive high-quality care through their comprehensive outpatient services, all within a nurturing and professional setting that addresses a wide variety of needs.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Midwest ADP
+1 photos

Midwest ADP

Kansas City Site

Kansas City, MO 64111
816-836-2220

Located in Kansas City, MO, Midwest ADP provides specialized substance use treatment programs designed for both adults and young adults. The center offers a range of treatment options, including intensive outpatient, outpatient, and regular outpatient services that are customized to meet individual needs. With a strong emphasis on 12-step facilitation, anger management, and brief intervention techniques, the facility ensures a thorough approach to care. What sets Midwest ADP apart is its commitment to developing individualized treatment plans that cater to the specific requirements of each client. Serving both men and women, this center prioritizes delivering high-quality care and support throughout the recovery process. If you are looking for effective and tailored addiction treatment, Midwest ADP is here to help you on your path to a healthier, substance-free life.

Substance use treatment
Mark Twain Behavioral Health

Mark Twain Behavioral Health

Macon, MO 63552
660-395-9114

Located in Macon, MO, Mark Twain Behavioral Health provides outpatient services for adults dealing with substance use and co-occurring mental health challenges, as well as for children experiencing emotional disturbances. The center is particularly skilled in anger management, substance use disorder counseling, and trauma-related therapy. They adopt a personalized approach, ensuring that treatment plans are tailored to meet the specific needs of each individual. Catering to both adults and children/adolescents, the facility accepts clients of all genders. With an emphasis on delivering high-quality and individualized care, Mark Twain Behavioral Health is dedicated to helping individuals navigate their recovery journeys through evidence-based practices and a team of compassionate professionals.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Mark Twain Behavioral Health

Mark Twain Behavioral Health

Moberly, MO 65270
573-248-1196

Located in Moberly, MO, Mark Twain Behavioral Health presents an extensive array of outpatient services focused on detoxification and substance use treatment. The center offers tailored programs specifically designed for adolescents, adult men, and adult women, addressing the needs of both adults and young adults. Utilizing various treatment strategies such as 12-step facilitation, anger management, and brief intervention, the facility prioritizes personalized care for every client. Whether in need of outpatient detoxification or day treatment programs, clients can look forward to receiving high-quality care customized to their unique requirements. Mark Twain Behavioral Health is welcoming to both male and female clients, fostering a nurturing environment conducive to recovery and healing.

DetoxificationSubstance use treatment
Gibson Recovery Center Inc - Placeholder

Gibson Recovery Center Inc

Sikeston, MO 63801
573-332-0416 x145

Gibson Recovery Center Inc, situated in Sikeston, MO, offers dedicated treatment for adults grappling with substance use issues, particularly those who also experience serious mental health challenges. This center features a range of services including intensive outpatient care and outpatient options, alongside specialized treatments with methadone, buprenorphine, or naltrexone. Their approach emphasizes counseling for substance use disorders, trauma-informed therapy, and provides convenient telemedicine services. Catering specifically to adult men and women, as well as those dealing with both mental health and substance use disorders, the facility ensures that individuals receive tailored support. Programs are designed to accommodate both adults and young adults, delivering comprehensive care for all genders who are seeking effective rehabilitation solutions.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Gibson Recovery Center Inc - Placeholder

Gibson Recovery Center Inc

Perryville, MO 63775
573-332-0416 x140

Gibson Recovery Center Inc, situated in Perryville, MO, provides a wide range of substance use treatment options for adults and young adults. At this facility, you'll find intensive outpatient programs, outpatient care, and methadone/buprenorphine treatment, specifically designed for those facing co-occurring mental health issues. The center focuses on substance use disorder counseling as well as trauma-related therapy, and it also offers the convenience of telemedicine services. With customized programs for adult men, women, and individuals with dual diagnoses, Gibson Recovery Center Inc is committed to delivering high-quality care for all patients on their journey to recovery from addiction.

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Guadalupe Centers Inc - Placeholder

Guadalupe Centers Inc

Kansas City, MO 64127
816-531-6911

Guadalupe Centers Inc, located in Kansas City, MO, offers outpatient substance use treatment geared toward adults and young adults. The center employs evidence-based methods, including cognitive behavioral therapy, contingency management with motivational incentives, and motivational interviewing in its regular outpatient program. Committed to providing personalized care, the facility develops tailored treatment plans that cater to the specific needs of every individual. Whether male or female, clients can expect a supportive and well-rounded environment as they work towards recovery from addiction. Discover exceptional care and customized treatment at this respected rehabilitation center.

Substance use treatment
Heartland Center for Behavioral Change - Placeholder

Heartland Center for Behavioral Change

Liberty Outpatient Clinic

Liberty, MO 64068
816-214-9110

Located in Liberty, MO, the Heartland Center for Behavioral Change specializes in substance use treatment for both adults and young adults. The center emphasizes intensive outpatient programs as well as outpatient treatment options involving methadone, buprenorphine, or naltrexone. Patients receive personalized care grounded in evidence-based methods including cognitive behavioral therapy, the Matrix Model, and motivational interviewing. One standout aspect of this facility is its customized programs designed specifically for criminal justice and forensic clients. Catering to both men and women, the Heartland Center offers comprehensive support to individuals on their journey to recovery from substance use disorders. With a strong commitment to providing quality care, it has established itself as a reliable resource for effective addiction treatment.

Substance use treatment
I Am Third - Placeholder

I Am Third

Saint Joseph, MO 64506
816-259-5306

"I Am Third," situated in Saint Joseph, MO, provides a thorough approach to substance use treatment with its various programs, including intensive outpatient, outpatient, and regular outpatient options. This facility focuses on 12-step facilitation, anger management, and brief intervention methods to tackle addiction concerns effectively. They offer specialized programs designed for adult men, adult women, and those who have faced intimate partner or domestic violence, ensuring personalized care for a diverse clientele. Committed to serving both adults and young adults of all genders, "I Am Third" strives to deliver top-notch rehabilitation services in a supportive and welcoming atmosphere.

Substance use treatment

Addiction Treatment in Missouri

Missouri's gateway cities of St. Louis and Kansas City offer extensive treatment networks serving the Midwest region. The state has developed strong prescription monitoring and expanded treatment access.

Treatment Landscape in Missouri

Missouri treatment centers serve as regional hubs for the Midwest. The state offers diverse options from major medical centers in the cities to rural community programs. Veterans services are particularly strong.

Why Choose Treatment in Missouri?
  • Central location accessible from many states
  • Strong veterans treatment programs
  • Urban and rural treatment options
  • Growing medication-assisted treatment access
Gateway city treatment hub
Prescription drug monitoring
Veterans programs

Major Treatment Areas in Missouri

Kansas CitySaint LouisSpringfieldColumbia
Insurance & Payment in Missouri

MO HealthNet (Medicaid) covers behavioral health services. Medicaid expansion has increased access.

Types of Treatment Available

  • Medical Detox: Safe, supervised withdrawal with 24/7 medical support
  • Residential Treatment: Live-in programs with structured daily therapy
  • Partial Hospitalization (PHP): Intensive day treatment programs
  • Intensive Outpatient (IOP): Flexible scheduling for working professionals
  • Standard Outpatient: Weekly therapy and support groups
  • Sober Living: Transitional housing for ongoing recovery support

Expert Tips for Missouri

Expert Tip

St. Louis and Kansas City serve as regional treatment hubs with diverse program options.

Expert Tip

Veterans programs are particularly strong in Missouri — ask about specialized services.

Expert Tip

Central location makes Missouri accessible for out-of-state patients seeking treatment.

Missouri Treatment Resources

Official state resources and organizations providing addiction treatment support in Missouri.

Missouri Department of Mental Health

State resource for addiction treatment in Missouri

MO HealthNet

State resource for addiction treatment in Missouri

National Resources

Federal resources and hotlines available 24/7 for addiction support.

Free, confidential, 24/7, 365-day-a-year treatment referral and information service

Find treatment facilities in your area

Provides 24/7 free and confidential support for people in distress

Research and information on drug use and addiction

Frequently Asked Questions

Important Notice

This website provides general information about addiction treatment facilities. It is not a substitute for professional medical advice, diagnosis, or treatment. If you are experiencing a mental health crisis, please call 988 (Suicide & Crisis Lifeline) or 911 for immediate assistance. For substance abuse help, call SAMHSA at 1-800-662-4357.

Data sourced from SAMHSA Treatment Locator, state licensing databases, and facility submissions.