Penn Spine and Rehab Logo

Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

Need Help Finding the Right Treatment?

Browse our directory or call to discuss treatment options.

Call 1(223) 235-7839
12,000+ Centers
SAMHSA Data
Filters:

Showing 20 of 8160 depression rehab centers

Naaman Center
+8 photos

Naaman Center

Elizabethtown, PA

Situated in Elizabethtown, PA, the Naaman Center provides a range of substance use treatment options, including intensive outpatient, outpatient, and programs using methadone/buprenorphine or naltrexone. The facility takes pride in its expertise in brief intervention, cognitive behavioral therapy, and community reinforcement with vouchers. With specialized programs designed for both adult men and women, as well as services catering to children and adolescents, the center is dedicated to offering customized care that addresses various needs. To foster a more supportive atmosphere, Naaman Center also provides gender-specific treatment options for both males and females. The center's commitment to quality addiction treatment is evident through its evidence-based methods and focus on individualized care for those on their path to recovery.

Community Medical Services
+8 photos

Community Medical Services

Minneapolis, MN

Situated in Minneapolis, MN, Community Medical Services provides outpatient treatment for substance use, emphasizing a personalized approach for both adults and young adults. The center offers a range of treatments, including methadone/buprenorphine or naltrexone, grounded in evidence-based practices like the Matrix Model, Motivational Interviewing, and Relapse Prevention. Each client's needs are met through tailored programs, ensuring a well-rounded treatment experience. Serving both male and female clients, the facility prides itself on fostering a caring and supportive atmosphere. If you’re looking for effective addiction treatment that puts you at the center of care, this facility is committed to helping you on your recovery journey.

Dundalk Health Services Inc
+8 photos

Dundalk Health Services Inc

Dundalk, MD

Dundalk Health Services Inc., based in Dundalk, MD, provides a wide range of substance use treatment options, including intensive outpatient, outpatient, and methadone/buprenorphine or naltrexone programs. This facility focuses on counseling for substance use disorders and offers the convenience of telemedicine and telehealth therapy. To promote a supportive and inclusive atmosphere, they have specialized programs designed for adult men, adult women, and LGBTQ individuals. Serving adults and young adults of all genders, Dundalk Health Services Inc. emphasizes quality care and personalized treatment plans to assist individuals on their path to recovery.

Hudson Hospital and Clinics
+8 photos

Hudson Hospital and Clinics

Hudson, WI

Hudson Hospital and Clinics, situated in Hudson, WI, provides a thorough range of substance use treatment options for both adults and young adults. The facility specializes in intensive outpatient programs, outpatient care, and regular outpatient services, focusing on personalized treatment plans. They employ various methods such as 12-step facilitation, relapse prevention techniques, and counseling for substance use disorders. With a commitment to tailoring interventions for each individual, the center serves clients of all genders. Hudson Hospital and Clinics is dedicated to offering top-notch care to assist individuals on their path to recovery from addiction.

VOA Addiction Recovery Services
+8 photos

VOA Addiction Recovery Services

Louisville, KY

Located in Louisville, KY, VOA Addiction Recovery Services offers a wide variety of substance use treatments tailored for adult women, seniors, and young adults who are dealing with serious mental health challenges at the same time. The center features intensive outpatient programs, long-term residential care, and standard outpatient options, implementing methods like 12-step facilitation, anger management, and brief interventions. Furthermore, there are specialized programs designed for those who have faced intimate partner violence, domestic violence, and sexual abuse. Committed to providing top-notch care, this facility strives to assist individuals in overcoming their addiction and mental health issues within a supportive and nurturing environment.

Applegate Recovery
+8 photos

Applegate Recovery

Bowling Green, KY

Applegate Recovery, located in Bowling Green, KY, specializes in outpatient treatment for substance use, prioritizing personalized care. The center offers outpatient services for adults and young adults of all genders, featuring methadone/buprenorphine or naltrexone treatments. By employing evidence-based strategies such as cognitive behavioral therapy, motivational interviewing, and relapse prevention, Applegate Recovery customizes treatment plans to fit the distinct needs of each individual. With a strong commitment to providing high-quality care, the facility is recognized for its tailored programs that effectively tackle the specific challenges encountered by those seeking assistance with addiction.

Metro Treatment of Florida LP
+8 photos

Metro Treatment of Florida LP

Daytona Beach, FL

Metro Treatment of Florida LP, located in Daytona Beach, FL, specializes in outpatient detoxification and treatment for substance use, catering to both adults and young adults. Their diverse programs incorporate cognitive behavioral therapy, motivational interviewing, and techniques aimed at preventing relapse. Emphasizing personalized care, this facility offers outpatient treatment options with methadone, buprenorphine, or naltrexone. Whether you’re male or female, Metro Treatment of Florida LP distinguishes itself through its customized approach to tackling addiction. If you're looking for high-quality care that prioritizes your individual needs, this center is committed to helping you on your journey to recovery.

Comprehensive Behavior Health Center
+8 photos

Comprehensive Behavior Health Center

East Saint Louis, IL

Situated in East Saint Louis, IL, the Comprehensive Behavior Health Center delivers a variety of specialized treatment options. Their offerings encompass services for substance use disorders, transitional housing, and support for those dealing with both substance use and serious mental health conditions. The center features long-term residential care, outpatient services, and outpatient options for methadone, buprenorphine, or naltrexone treatment. Utilizing methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy, the center serves a diverse clientele, including adults, adolescents, and active duty military personnel. There are customized programs designed specifically for adult men, women, and various age demographics. Committed to providing high-quality care to individuals on their journey to recovery, this facility is distinguished by its comprehensive and tailored treatment services.

Ocala Consulting and Prevention LLC
+8 photos

Ocala Consulting and Prevention LLC

Ocala, FL

Ocala Consulting and Prevention LLC, located in Ocala, FL, offers outpatient substance use treatment for adults grappling with serious mental health issues and for children facing emotional disturbances. This center features tailored programs for adolescents, adult men, and adult women, providing support that recognizes the unique needs of each gender. Their treatment methods include anger management, cognitive behavioral therapy, and motivational interviewing. Additionally, the facility offers outpatient options such as methadone, buprenorphine, or naltrexone treatments, ensuring a well-rounded approach to recovery for those seeking help. With a strong emphasis on quality care and personalized treatment plans, Ocala Consulting and Prevention LLC stands out as an essential resource for individuals in need of addiction support.

Will Rogers Health Center
+8 photos

Will Rogers Health Center

Nowata, OK

Situated in Nowata, OK, the Will Rogers Health Center is dedicated to offering a well-rounded selection of substance use treatment programs specifically designed for adults and seniors. This facility excels in addressing co-occurring substance use disorders along with serious mental health challenges in adults, as well as significant emotional disturbances in children. With a variety of treatment formats available—such as intensive outpatient, outpatient, and regular outpatient services—the center is committed to providing personalized care that caters to the unique needs of each client. By employing strategies like 12-step facilitation, anger management, and brief interventions, the center strives to deliver high-quality care to all clients, regardless of gender. The facility's strong focus on individualized treatment ensures that everyone receives tailored support as they navigate their path to recovery.

Community Behavioral Health
+8 photos

Community Behavioral Health

Hamilton, OH

Situated in Hamilton, OH, Community Behavioral Health provides an array of comprehensive treatment options designed for both adults and children dealing with substance use and mental health issues. The facility offers a variety of services, including intensive outpatient treatment, outpatient day programs, and partial hospitalization. Their approach features techniques such as anger management, cognitive behavioral therapy, and brief interventions. Community Behavioral Health also has specialized programs tailored for active duty military personnel, adolescents, and adult men, catering to a wide range of individuals. With a keen focus on personalized care, the center addresses the needs of adults and seniors while also offering distinct programs for males and females. Patients can look forward to receiving high-quality care that emphasizes holistic healing and supports their journey to recovery.

Teen Project Outpatient
+8 photos

Teen Project Outpatient

Rancho Santa Margarita, CA

Teen Project Outpatient, situated in Rancho Santa Margarita, CA, specializes in providing targeted treatment for adults and young adults dealing with substance use issues alongside serious mental health challenges. The facility offers both intensive outpatient and outpatient programs, employing evidence-based methods such as 12-step facilitation, cognitive-behavioral therapy, and brief interventions. With a strong emphasis on personalized care, the team at Teen Project Outpatient customizes treatment plans to address the distinct needs of each individual. This center welcomes both male and female clients, including those looking for outpatient options like methadone/buprenorphine or naltrexone treatment, demonstrating a commitment to delivering quality support as individuals navigate their recovery journey.

New Choices
+8 photos

New Choices

Trenton, NJ

Situated in Trenton, NJ, New Choices provides a wide array of rehabilitation services tailored for individuals facing challenges related to substance use as well as co-occurring mental health issues. The center features several treatment options, including intensive outpatient, outpatient, and standard outpatient programs. Emphasizing evidence-based methods like anger management, brief intervention, and cognitive behavioral therapy, New Choices serves adults, children, adolescents, and young adults of all genders. Additionally, there are specialized programs designed for clients who have experienced trauma or are dealing with both mental health and substance use disorders. Experience compassionate care and effective treatment at New Choices.

Duane Dean Behavioral Health Center
+8 photos

Duane Dean Behavioral Health Center

Kankakee, IL

Situated in Kankakee, IL, the Duane Dean Behavioral Health Center delivers a wide array of addiction treatment options for both adults and children. The facility specializes in intensive outpatient treatment, outpatient detoxification, and various outpatient services. Their methods include 12-step facilitation, cognitive behavioral therapy, and brief intervention. Additionally, they offer tailored programs for adult men, women, and those who are part of the criminal justice system. With an emphasis on addressing co-occurring substance use and mental health disorders, the center is dedicated to supporting adults, seniors, and young adults across all genders. The Duane Dean Behavioral Health Center prioritizes high-quality care to aid individuals as they navigate their recovery journey.

MedMark Jacksonville
+8 photos

MedMark Jacksonville

Jacksonville, FL

MedMark Jacksonville, located in Jacksonville, FL, provides outpatient treatment programs focused on substance use, including specialized options for methadone, buprenorphine, or naltrexone therapy. The center utilizes proven methods such as cognitive behavioral therapy, contingency management/motivational incentives, and motivational interviewing to support clients. Emphasizing personalized care, MedMark Jacksonville serves adults and young adults of all genders. What sets this facility apart is its commitment to creating comprehensive treatment plans that cater to the individual needs of each client, ensuring they receive high-quality care and support throughout their recovery process. If you're looking for effective addiction treatment combined with a personal touch, this center is here to help you achieve long-lasting sobriety.

Victory Clinical Services
+8 photos

Victory Clinical Services

Kalamazoo, MI

Victory Clinical Services, situated in Kalamazoo, MI, provides a wide array of addiction treatment services. This facility focuses on detoxification, substance use treatment, and addressing co-occurring disorders for both adults and children. With options for intensive outpatient and outpatient care, the center employs various therapeutic methods, including anger management, cognitive behavioral therapy, and brief interventions. What sets Victory Clinical Services apart is its dedicated programs for survivors of intimate partner violence, sexual abuse, and trauma. Catering to individuals of all genders, the facility emphasizes personalized care and tailored treatment plans to help clients navigate their recovery journey.

RAPHA Healthcare Services
+8 photos

RAPHA Healthcare Services

Mooresville, NC

RAPHA Healthcare Services, located in Mooresville, NC, provides a wide range of substance use treatment options along with specialized care for individuals dealing with both substance use disorders and serious mental health issues. Their offerings include intensive outpatient programs, standard outpatient services, and outpatient treatments featuring methadone, buprenorphine, or naltrexone. The center emphasizes evidence-based practices, such as anger management, cognitive behavioral therapy, and motivational interviewing, to support their clients effectively. They serve adult men and women, as well as individuals who have faced intimate partner violence or domestic violence. Prioritizing adults and young adults, RAPHA Healthcare Services is committed to delivering high-quality care that is tailored to the specific needs of each person, utilizing a gender-sensitive approach to address both male and female clients.

New Hope Ranch
+8 photos

New Hope Ranch

Manor, TX

Situated in Manor, TX, New Hope Ranch is a respected rehabilitation center that provides a wide range of services for adult men dealing with substance use issues and serious co-occurring mental health disorders. This facility excels in hospital inpatient detoxification and treatment, offering tailored programs that include 12-step facilitation and anger management. What sets New Hope Ranch apart is its emphasis on helping clients who have faced intimate partner violence, domestic violence, or sexual abuse. Committed to delivering quality care, the center caters to adults, seniors, and young adults, creating a nurturing environment for male clients on their journey to recovery from both addiction and mental health struggles.

Stress Care of New Jersey LLC
+8 photos

Stress Care of New Jersey LLC

Matawan, NJ

Located in Matawan, NJ, Stress Care of New Jersey LLC specializes in rehabilitation services that address substance use and serious mental health issues in adults, as well as emotional disturbances in children. The center features a range of programs, including intensive outpatient, outpatient, and partial hospitalization offerings, all designed to meet the unique needs of each client. Emphasizing techniques like anger management, cognitive behavioral therapy, and motivational interviewing, this facility serves a diverse clientele, including active duty military personnel, adolescents, and adult men. With a commitment to supporting both adults and children, as well as accommodating clients of all genders, Stress Care of New Jersey LLC is recognized for its comprehensive and personalized approach to the recovery process.

University Behavioral Center
+8 photos

University Behavioral Center

Orlando, FL

Located in Orlando, FL, the University Behavioral Center provides a wide range of treatment options for detoxification and substance use. The facility has a particular emphasis on addressing co-occurring severe mental health issues in adults as well as emotional disturbances in children. They offer inpatient detoxification services and treatment around the clock, ensuring that care is always available. The center utilizes customized strategies like 12-step facilitation, anger management, and brief interventions. This makes it a perfect fit for various populations, including active duty military personnel, adult men, and those who have faced intimate partner violence. Catering to both adults and children or adolescents of all genders, the University Behavioral Center is dedicated to delivering high-quality care. Their approach focuses on personalized programs aimed at helping individuals navigate their recovery journey.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • •Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • •Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • •Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • •Genetic predisposition — shared hereditary risk factors for both conditions
  • •Childhood trauma and adverse experiences
  • •Chronic stress, grief, loss, or major life changes
  • •Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab