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Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

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Showing 20 of 8160 depression rehab centers

Groups Recover Together
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Groups Recover Together

Calais, ME

Located in Calais, ME, Groups Recover Together provides outpatient treatment for substance use tailored specifically for adults and young adults. Their individualized approach encompasses crucial elements such as relapse prevention, counseling for substance use disorders, and access to telemedicine and telehealth therapy. This facility offers outpatient treatments using methadone, buprenorphine, or naltrexone, ensuring that clients receive comprehensive care. With a commitment to quality and personalized support, Groups Recover Together is open to male and female clients alike. If you’re on the hunt for effective addiction treatment in a supportive setting, you might find that this program's focus on individualized care and varied treatment options meets your needs perfectly.

Intermountain Community Services
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Intermountain Community Services

Helena, MT

Intermountain Community Services, situated in Helena, MT, provides a variety of evidence-based treatment options for those facing challenges with substance use as well as co-occurring mental health issues. The center features intensive outpatient, outpatient, and regular outpatient programs, employing methods like brief intervention, cognitive behavioral therapy, and motivational interviewing. With specialized programs designed for active-duty military personnel, adolescents, and adult men, the facility caters to adults and seniors regardless of gender. Committed to delivering high-quality care, Intermountain Community Services focuses on the unique needs of every individual, supporting clients on their journey toward lasting recovery and enhanced overall well-being.

Southern Iowa Economic Dev Association
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Southern Iowa Economic Dev Association

Fairfield, IA

Located in Fairfield, IA, the Southern Iowa Economic Development Association provides extensive treatment for substance use as well as specialized support for adults and children experiencing co-occurring substance use and mental health disorders. This center offers a range of outpatient services, which include anger management, brief interventions, and cognitive behavioral therapy. They have tailored programs specifically designed for adolescents, trauma survivors, and those with dual diagnoses, ensuring that they are able to meet the needs of adults and seniors across all genders. Recognized for its quality of care and evidence-based methods, this facility stands out as a vital resource for individuals seeking effective and compassionate rehabilitation services.

New Season of Ohio LP
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New Season of Ohio LP

Akron, OH

Situated in Akron, OH, New Season of Ohio LP delivers a wide range of substance use treatment options through its outpatient programs. The center specializes in outpatient treatments with methadone/buprenorphine or naltrexone, regular outpatient therapy, and employs evidence-based practices such as anger management, cognitive behavioral therapy, and contingency management/motivational incentives. Prioritizing personalized care, this facility serves adult men, adult women, pregnant or postpartum women, as well as young adults of all genders. What sets New Season of Ohio LP apart is its commitment to offering specialized programs and high-quality addiction treatment services for those on their journey to recovery.

Adult and Child Health
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Adult and Child Health

Indianapolis, IN

Located in Indianapolis, IN, Adult and Child Health delivers specialized outpatient services for adults dealing with substance use and co-occurring serious mental health challenges, as well as for children facing significant emotional disturbances. The center features regular outpatient programs that incorporate brief interventions, cognitive behavioral therapy, and motivational interviewing techniques. What sets this facility apart is its commitment to personalized care, serving adults and seniors of all genders. With a strong emphasis on creating individualized treatment plans, clients receive high-quality support tailored to their unique needs. If you’re looking for effective and customized addiction treatment services, this center offers a comprehensive approach to help you on your recovery journey.

MedMark Treatment Centers
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MedMark Treatment Centers

Essex, MD

Located in Essex, MD, MedMark Treatment Centers delivers a wide array of addiction treatment services. With expertise in detoxification, substance use treatment, and co-occurring disorders, this facility offers both intensive outpatient and outpatient programs, including options for outpatient detoxification. The center emphasizes a range of therapeutic approaches, such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, catering to diverse groups including adult men and women, pregnant or postpartum women, and young adults. Their customized programs focus on the specific needs of each individual, providing quality care and support throughout the recovery process. If you’re looking for evidence-based treatment in a nurturing environment, MedMark Treatment Centers is ready to assist you.

Lowell House Inc
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Lowell House Inc

Lowell, MA

Lowell House Inc, located in Lowell, MA, provides specialized care for substance use issues and co-occurring disorders, catering to both adults and children. Their range of programs includes intensive outpatient treatment, outpatient day treatment, and partial hospitalization. Emphasizing evidence-based methods like cognitive behavioral therapy and anger management, the center designs its services to meet diverse needs. Tailored programs are available specifically for adult men, adult women, and clients involved with the criminal justice system. With a commitment to gender-specific treatment, Lowell House Inc ensures that male and female clients receive the support they need. Their dedication to quality care and personalized treatment options makes them a leading choice for individuals seeking effective rehabilitation services.

Evoke at Entrada LLC
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Evoke at Entrada LLC

Santa Clara, UT

Evoke at Entrada LLC, located in Santa Clara, UT, provides extensive long-term residential treatment for substance use disorders, along with specialized care for adults facing serious mental health issues or children dealing with significant emotional disturbances. The center is dedicated to offering 24-hour residential support, employing evidence-based methods such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. Their programs are designed to meet the needs of various populations, including adolescents, those who have survived sexual abuse, and individuals who have experienced trauma. Catering to adults and children/adolescents of all genders, Evoke at Entrada LLC is committed to providing high-quality, personalized treatment aimed at fostering lasting recovery for every individual who walks through its doors.

Spero Health
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Spero Health

Indianapolis, IN

Located in Indianapolis, IN, Spero Health delivers a wide range of outpatient services aimed at treating addiction. Their offerings include detoxification and various substance use treatment options. The facility specializes in outpatient programs, offering treatment with methadone, buprenorphine, or naltrexone. Spero Health emphasizes the 12-step approach, anger management strategies, and brief intervention techniques. They serve adult men and women, including those who have faced intimate partner or domestic violence situations. With specialized programs tailored for both adults and young adults of all genders, the center prioritizes individualized care for everyone who walks through their doors. Committed to high standards and evidence-based practices, Spero Health provides a nurturing environment where individuals can focus on their journey toward recovery from addiction.

Camden Treatment Associates
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Camden Treatment Associates

Camden, NJ

Camden Treatment Associates, located in Camden, NJ, provides a wide array of substance use treatment options, including intensive outpatient programs, regular outpatient services, and outpatient day treatment. The center utilizes evidence-based methods like 12-step facilitation, anger management, and cognitive behavioral therapy. They offer specialized programs designed for adult men, adult women, and pregnant or postpartum women, which allows them to serve a diverse clientele effectively. Catering to adults and young adults of all genders, Camden Treatment Associates is committed to delivering high-quality care that addresses the unique needs of each individual.

Living Legacy Inc
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Living Legacy Inc

Memphis, TN

Living Legacy Inc, located in Memphis, TN, provides a full range of substance use treatment services for adults facing serious mental health challenges, as well as support for children experiencing emotional disturbances. The center features intensive outpatient programs, standard outpatient care, and specialized treatment options using methadone/buprenorphine or naltrexone. With a strong emphasis on anger management, brief interventions, and cognitive behavioral therapy, Living Legacy Inc tailors its services to meet the needs of adolescents, men, and women alike. Committed to delivering quality care, this facility supports both adults and seniors of all genders in their recovery journeys through its specialized programs.

Road to Recovery Lawrence LLC
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Road to Recovery Lawrence LLC

Wichita, KS

Located in Wichita, KS, Road to Recovery Lawrence LLC specializes in outpatient treatment designed for adults and children dealing with substance use and co-occurring mental health disorders. The center offers a variety of programs, such as outpatient treatment with methadone, buprenorphine, or naltrexone, as well as 12-step facilitation, anger management, and brief interventions. With a strong commitment to personalized care, the facility serves adolescents, adult men, and women, creating a nurturing atmosphere for everyone. Road to Recovery Lawrence LLC is dedicated to supporting individuals on their path to sobriety through high-quality, evidence-based treatment options.

ANEW Chemical Health Services
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ANEW Chemical Health Services

Saint Paul, MN

ANEW Chemical Health Services, located in Saint Paul, MN, is dedicated to providing thorough treatment for substance use, along with specialized support for those facing serious mental health challenges. The facility features a variety of programs, such as intensive outpatient, long-term residential, and outpatient options, designed specifically for adults and young adults. The treatment approach at ANEW is distinct, incorporating elements like 12-step facilitation, anger management, and cognitive behavioral therapy. They also offer special programs aimed at adult women, including those who have survived intimate partner violence, domestic violence, and sexual abuse. By providing gender-specific care, the center ensures that women can find a safe and nurturing environment to embark on their recovery journey. Clients can look forward to receiving personalized care aimed at guiding them toward healing and lasting sobriety.

Access Westside Family Health
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Access Westside Family Health

Chicago, IL

Access Westside Family Health in Chicago, IL, provides outpatient substance use treatment specifically designed for adults and young adults dealing with serious co-occurring mental health issues. Their extensive range of programs features outpatient treatments such as methadone, buprenorphine, or naltrexone, along with cognitive behavioral therapy and the Matrix Model approach. The center serves both men and women, including clients living with HIV or AIDS, offering tailored care to address each individual's unique needs. With an emphasis on brief interventions and high-quality care, the facility is dedicated to supporting clients throughout their recovery journey. Access Westside Family Health is open to all, creating a safe and welcoming atmosphere for anyone seeking treatment.

DUI and Behavioral Health Csl Servs
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DUI and Behavioral Health Csl Servs

Plano, IL

DUI and Behavioral Health Counseling Services in Plano, IL, is dedicated to providing thorough substance use treatment for both adults and children who are also dealing with mental health challenges. The center offers a range of treatment options, including intensive outpatient, outpatient, and regular outpatient programs. With services specifically designed for adolescents, as well as adult men and women, this facility effectively supports a wide variety of age groups and genders. The center employs diverse therapeutic methods such as 12-step facilitation, anger management strategies, and brief interventions, all while emphasizing a holistic approach to recovery. Clients can look forward to receiving personalized, high-quality care that meets their unique needs, making this facility an invaluable resource for anyone seeking effective addiction treatment.

Synergy Homecare
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Synergy Homecare

Philadelphia, PA

Synergy Homecare, located in Philadelphia, PA, specializes in outpatient substance use treatment for both adults and children who are facing serious mental health challenges or emotional disturbances. The center employs a variety of evidence-based methods, including 12-step facilitation, anger management, and brief interventions, to support its clients. What sets Synergy Homecare apart is its commitment to providing personalized care; each program is customized to address the individual needs of every client. Catering to adults and seniors of all genders, the facility prioritizes delivering quality support in a nurturing atmosphere. If you or someone you care about is looking for targeted addiction treatment in Philadelphia, Synergy Homecare offers extensive and tailored rehabilitation services to assist in the recovery journey.

TLC Treatment Center
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TLC Treatment Center

Mesa, AZ

TLC Treatment Center, situated in Mesa, AZ, delivers a wide range of services for substance use treatment, including options for transitional housing and sober living. The center features intensive outpatient programs alongside outpatient and partial hospitalization services. With an emphasis on 12-step facilitation, anger management, and brief interventions, TLC serves adult men and women, including those who have faced sexual abuse. Catering to both adults and young adults, the center provides gender-specific programs designed specifically for females and males. Driven by a commitment to high-quality care and personalized treatment strategies, TLC Treatment Center is devoted to guiding clients through their recovery journey.

Reflections Family Services Inc
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Reflections Family Services Inc

Tucson, AZ

Reflections Family Services Inc, situated in Tucson, AZ, provides outpatient treatment for adults and young adults dealing with substance use issues. The facility focuses on key areas such as anger management, relapse prevention, and counseling for substance use disorders, ensuring a personalized approach for each client. With programs catering to both males and females, they create a comprehensive and inclusive treatment environment. The skilled team at Reflections Family Services Inc is committed to delivering excellent care and support to individuals on their journey towards overcoming addiction and attaining lasting recovery.

Pine Rest Christian Mental Hlth Servs
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Pine Rest Christian Mental Hlth Servs

Holland, MI

Situated in Holland, MI, Pine Rest Christian Mental Health Services delivers a variety of specialized treatment programs designed for adults and young adults facing substance use challenges alongside mental health concerns. The center offers outpatient services, such as methadone and buprenorphine treatments, specifically adapted to address individual needs. Pine Rest emphasizes a range of therapeutic approaches, including 12-step facilitation, anger management, and brief interventions. This inclusive facility supports both men and women, with particular attention to those who have encountered trauma. With dedicated programs for adult men, adult women, and trauma survivors, Pine Rest fosters a thorough and nurturing environment conducive to recovery.

Spence Counseling Center
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Spence Counseling Center

Omaha, NE

Spence Counseling Center, situated in Omaha, NE, provides outpatient treatment for substance use and specialized care for those facing both substance use issues and serious mental health conditions, along with support for children dealing with emotional disturbances. They offer customized programs that encompass anger management, brief interventions, and cognitive behavioral therapy. With a dedicated focus on personalized care, the center serves adults and seniors of all genders. Known for its commitment to delivering quality treatment in a supportive setting, Spence Counseling Center stands out as an excellent choice for individuals seeking effective rehabilitation services in the area.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab