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Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

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Showing 20 of 8160 depression rehab centers

APT Foundation Inc
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APT Foundation Inc

New Haven, CT

APT Foundation Inc, located in New Haven, CT, provides a variety of evidence-based treatment programs designed for both substance use and co-occurring mental health issues for adults and children. The center offers intensive outpatient and outpatient options, which include methadone/buprenorphine treatment. Their dedicated team ensures personalized care through a range of methods such as 12-step facilitation, anger management, and brief interventions. What sets APT Foundation apart are its specialized programs tailored for active duty military members, as well as for adult men and women. The facility is committed to offering high-quality care and support to both adults and young adults of all genders who are on the path to recovery from addiction and addressing concurrent mental health challenges.

Towns Health Services/Lodi
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Towns Health Services/Lodi

Lodi, CA

At Towns Health Services/Lodi, located in Lodi, CA, individuals can find specialized treatment for substance use issues, including those with co-occurring substance use disorders and serious mental health conditions in adults, as well as serious emotional disturbances in children. This facility provides a range of options, including intensive outpatient treatment, outpatient care, and outpatient day programs or partial hospitalization. Utilizing methods like 12-step facilitation, anger management, and brief intervention, the center is dedicated to supporting both adult men and women, along with active duty military personnel. Catering to adults and young adults of any gender, Towns Health Services/Lodi focuses on delivering high-quality care through personalized treatment plans and evidence-based approaches.

New Life Treatment Center
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New Life Treatment Center

Worthington, MN

Located in Worthington, MN, New Life Treatment Center provides a wide range of substance use treatment programs. This facility is dedicated to offering specialized support for adults who are dealing with both substance use disorders and serious mental health issues. Treatment options here are varied, including intensive outpatient, regular outpatient, and general outpatient programs. New Life Treatment Center employs proven, evidence-based methods, incorporating strategies like 12-step facilitation, anger management, and brief interventions. With specialized programs designed for both adult men and women, the center serves a diverse group of clients. Catering to adults and young adults of all genders, the focus remains on delivering high-quality care that aids individuals as they navigate their recovery journey.

Burrell Behavioral Health
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Burrell Behavioral Health

Kansas City, MO

Situated in Kansas City, MO, Burrell Behavioral Health is dedicated to delivering exceptional substance use treatment within a residential environment. This facility features specialized programs designed for adult men, individuals navigating co-occurring mental health and substance use disorders, and those involved in the forensic system. At Burrell, there's an emphasis on 12-step facilitation, catering to a diverse clientele, including adults, seniors, and young adults who are in need of comprehensive care. With both short-term and 24-hour residential programs, the center ensures that male clients receive continuous support. Known for its high-quality care and personalized approaches, Burrell Behavioral Health is truly committed to empowering individuals on their journey to lasting recovery.

Shawnee Healthcare
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Shawnee Healthcare

Murphysboro, IL

Shawnee Healthcare, situated in Murphysboro, IL, provides specialized outpatient services focused on substance use, co-occurring mental health challenges, and emotional disturbances for both adults and children. Their treatment approaches are evidence-based and encompass anger management, brief interventions, and cognitive behavioral therapy. With programs specifically designed for adult men and women, Shawnee Healthcare fosters a nurturing environment conducive to recovery. This facility caters to adults and young adults of all genders, offering outpatient treatments such as methadone, buprenorphine, or naltrexone, in addition to standard outpatient care. At Shawnee Healthcare, individuals can expect quality care and customized treatment plans that empower them to overcome addiction and enhance their mental well-being.

BHG Brainerd Treatment Center
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BHG Brainerd Treatment Center

Brainerd, MN

Situated in Brainerd, MN, BHG Brainerd Treatment Center provides outpatient treatment for substance use, offering options like methadone, buprenorphine, or naltrexone. The center is well-versed in various therapeutic methods including brief interventions, cognitive behavioral therapy, and motivational interviewing. They have tailored programs designed specifically for adult men, adult women, and pregnant or postpartum women. The facility welcomes both adults and young adults, serving clients of all genders. By emphasizing personalized care and utilizing evidence-based practices, BHG Brainerd Treatment Center is committed to delivering high-quality addiction treatment services in a nurturing and understanding atmosphere.

BHG Knoxville Citico Treatment Center
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BHG Knoxville Citico Treatment Center

Knoxville, TN

In Knoxville, TN, you’ll find the BHG Knoxville Citico Treatment Center, which specializes in intensive outpatient treatment, outpatient services, and outpatient detoxification for both adults and young adults who are seeking help for substance use and detoxification. The center employs various strategies, such as anger management, brief intervention, and cognitive behavioral therapy, to create customized programs that meet the specific needs of each individual. With a strong emphasis on providing high-quality care, the center serves both male and female clients. What truly sets BHG Knoxville Citico Treatment Center apart is its dedication to personalized treatment plans and evidence-based practices, making it a vital resource for anyone striving to overcome addiction.

KaraLee and Associates PC
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KaraLee and Associates PC

Plymouth, MI

KaraLee and Associates PC, situated in Plymouth, MI, provides a wide range of substance use treatment options for adults, children, and adolescents. The center offers outpatient services, regular outpatient treatment, and residential programs designed to meet individual needs. They specialize in anger management, cognitive behavioral therapy, and relapse prevention, utilizing a personalized approach to rehabilitation. With an emphasis on creating a welcoming and inclusive atmosphere, KaraLee and Associates PC is open to both male and female clients. For anyone in search of effective, personalized care for substance use disorders, this center truly shines as a symbol of hope and recovery.

Solas Health PLLC
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Solas Health PLLC

Pinehurst, NC

Solas Health PLLC, located in Pinehurst, NC, provides a wide range of outpatient substance use treatment options, including therapies with methadone, buprenorphine, or naltrexone. The center focuses on cognitive behavioral therapy, counseling for substance use disorders, and offers both telemedicine and telehealth services. They have customized programs designed for active duty military personnel, as well as for adult men and women, ensuring that they meet various individual needs. This facility serves both adults and young adults, regardless of gender, and is dedicated to delivering personalized care within a friendly and supportive environment. Clients can look forward to receiving quality treatment from a team of experienced professionals, making Solas Health PLLC an excellent option for those in search of effective and individualized addiction rehabilitation services.

Good News Home Inc
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Good News Home Inc

Flemington, NJ

Good News Home Inc, located in Flemington, NJ, provides a variety of rehabilitation services designed specifically for adult women dealing with substance use issues along with co-occurring mental health challenges. The center features specialized programs aimed at supporting survivors of intimate partner violence, domestic violence, and sexual abuse, ensuring a safe and nurturing atmosphere for recovery. Their treatment methods include 12-step facilitation, anger management, and brief interventions, and they offer a range of options such as hospital inpatient care, long-term residential stay, and 24-hour inpatient treatment. Catering to adults, seniors, and young adults alike, this facility is committed to delivering exceptional care to help each individual find lasting healing and improved well-being.

Gaudenzia DRC Inc
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Gaudenzia DRC Inc

Philadelphia, PA

Situated in Philadelphia, PA, Gaudenzia DRC Inc provides a variety of specialized services for people looking for help with substance use, as well as support for co-occurring mental health issues. The facility offers intensive outpatient treatment, outpatient care, and outpatient options for methadone, buprenorphine, or naltrexone treatment. With techniques like 12-step facilitation, anger management, and brief interventions, Gaudenzia DRC Inc serves both adult men and women, including clients who have faced intimate partner violence. Focusing on adults and young adults, the center is dedicated to delivering quality care that meets the unique needs of each individual, making it an excellent choice for those in search of comprehensive and personalized rehabilitation services.

Gateway Rehab
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Gateway Rehab

Mount Pleasant, PA

Gateway Rehab, situated in Mount Pleasant, PA, offers a wide array of treatment options, encompassing detoxification and support for those dealing with substance use issues. The facility features residential detoxification services, round-the-clock residential care, and short-term residential programs designed for adults and young adults, regardless of gender. By employing methods like 12-step facilitation, anger management techniques, and brief interventions, Gateway Rehab tailors its treatment plans to meet the unique needs of each client. With an emphasis on personalized care, the facility is dedicated to providing high-quality support as clients embark on their recovery journey.

Metro Treatment of Florida LP
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Metro Treatment of Florida LP

Sarasota, FL

Located in Sarasota, FL, Metro Treatment of Florida LP provides outpatient detoxification and substance use treatment tailored for both adults and young adults. This center specializes in offering outpatient services that include methadone, buprenorphine, and naltrexone treatments. With a strong emphasis on motivational interviewing, relapse prevention, and counseling for substance use disorders, clients receive support that is customized to their unique needs. The facility prides itself on delivering individualized care, accommodating both male and female clients who are committed to effective and personalized addiction treatment. Thanks to its comprehensive programs and a dedicated team of experienced professionals, individuals battling substance use disorders can expect high-quality support in a nurturing and professional setting.

Bradford Health Services
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Bradford Health Services

Mobile, AL

Bradford Health Services, located in Mobile, AL, specializes in treating substance use disorders through a variety of programs, including intensive outpatient, outpatient, and options for methadone/buprenorphine or naltrexone. This facility uniquely offers 12-step facilitation, anger management sessions, and brief intervention strategies to meet the varying needs of each individual. Catering specifically to adult men and women, as well as services for both adults and young adults, they ensure that care is customized to address the diverse demographics they serve. Bradford Health Services takes pride in providing high-quality, gender-specific treatment tailored to both males and females. If you or someone you care about is in need of comprehensive addiction treatment in Mobile, this facility fosters a nurturing environment that supports recovery and wellness.

ProHealth Care
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ProHealth Care

Hartland, WI

ProHealth Care, located in Hartland, WI, specializes in outpatient treatment for both substance use issues and co-occurring mental health conditions, serving both adults and children. The facility employs various methods, including anger management, brief interventions, and cognitive behavioral therapy, specifically designed for clients with dual diagnoses. Offering customized programs for adults and children/adolescents of all genders, ProHealth Care is dedicated to delivering comprehensive care that addresses a wide range of needs. Their emphasis on integrated treatment for co-occurring disorders allows for a well-rounded approach to recovery. Patients can look forward to high-quality care and personalized support to help them on their path to long-term wellness.

Positive Impact Health Centers Inc
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Positive Impact Health Centers Inc

Decatur, GA

Located in Decatur, GA, Positive Impact Health Centers Inc offers a variety of specialized treatment programs designed for adults and young adults facing challenges related to substance use and co-occurring mental health issues. The center provides both intensive outpatient and outpatient services, which include treatment options such as methadone, buprenorphine, or naltrexone. With an emphasis on cognitive behavioral therapy, anger management, and brief interventions, the facility customizes its treatment plans to meet the unique needs of each client. They also have distinct programs specifically for individuals who have experienced trauma, those living with HIV or AIDS, and those dealing with co-occurring disorders. Positive Impact Health Centers Inc is dedicated to serving both male and female clients, offering thorough care aimed at fostering recovery and enhancing overall well-being.

Shawnee Healthcare
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Shawnee Healthcare

Carbondale, IL

Shawnee Healthcare, situated in Carbondale, IL, provides a wide range of outpatient services for those dealing with substance use disorders and co-occurring mental health issues, supporting both adults and children. The facility features tailored programs designed for adult men and women, as well as young adults, and utilizes evidence-based methods such as anger management, cognitive behavioral therapy, and brief interventions. Prioritizing high-quality care, Shawnee Healthcare offers outpatient treatment options for methadone/buprenorphine or naltrexone, in addition to standard outpatient services. This center is dedicated to assisting both male and female clients in finding effective and individualized rehabilitation solutions.

Community Action Against Addiction
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Community Action Against Addiction

Cleveland, OH

Community Action Against Addiction, based in Cleveland, OH, provides a wide range of substance use treatment options. They offer programs in various formats, including intensive outpatient, outpatient, and treatments with methadone, buprenorphine, or naltrexone. The facility focuses on customized care, incorporating methods like anger management, cognitive behavioral therapy, and the Matrix Model. They also have specialized programs designed for adult men, adult women, and individuals who have experienced intimate partner or domestic violence. Catering to both adults and young adults of all genders, this center is committed to delivering high-quality support to help individuals on their recovery journey.

Spokane Addiction Recovery Centers
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Spokane Addiction Recovery Centers

Spokane, WA

Spokane Addiction Recovery Centers stands out as a professional rehabilitation facility offering top-notch addiction treatment services.

Samaritan Daytop Village Inc
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Samaritan Daytop Village Inc

Jamaica, NY

Samaritan Daytop Village Inc, located in Jamaica, NY, provides a wide range of addiction treatment services designed for both adults and children/adolescents. Their offerings include detoxification, substance use treatment, and specialized care for individuals wrestling with co-occurring substance use issues and serious mental health challenges. The center has various treatment options available, such as intensive outpatient programs, outpatient services, and outpatient detoxification. Using evidence-based methods like anger management, brief intervention, and cognitive behavioral therapy, the facility aims to foster effective healing. Additionally, they cater to specific populations with unique programs for active duty military personnel, adolescents, and adult men, ensuring that both male and female clients receive the quality care they need on their journey to recovery from addiction.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab