Penn Spine and Rehab Logo

Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

Need Help Finding the Right Treatment?

Browse our directory or call to discuss treatment options.

Call 1(223) 235-7839
12,000+ Centers
SAMHSA Data
Filters:

Showing 20 of 8160 depression rehab centers

Nova Behavioral Health Inc
+1 photos

Nova Behavioral Health Inc

Dayton, OH

Situated in Dayton, OH, Nova Behavioral Health Inc offers a wide array of addiction treatment services, which include detoxification, substance use therapy, and transitional housing alternatives like halfway houses and sober living environments. The center provides various programs, including intensive outpatient, long-term residential, and standard outpatient options, all employing evidence-based practices such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. Nova Behavioral Health also features specialized programs for active duty military members, as well as distinct services for adult men and women, addressing the needs of a broad spectrum of clients. By focusing on both adults and young adults, the center ensures high-quality, personalized care that meets the unique requirements of each individual.

Ram Recovery
+1 photos

Ram Recovery

Baltimore, MD

Situated in Baltimore, MD, Ram Recovery specializes in offering treatment programs for both adults and young adults dealing with substance use issues. The center features a range of options including intensive outpatient programs, standard outpatient care, and treatments using methadone, buprenorphine, or naltrexone. With an emphasis on 12-step facilitation, anger management, and cognitive behavioral therapy, Ram Recovery personalizes its services to cater to the unique needs of each client. The center also proudly provides distinct programs tailored for adult men and women, as well as clients who have faced intimate partner violence or domestic violence. By accommodating both male and female clients, Ram Recovery fosters a comprehensive and supportive environment for individuals seeking help with their addictions.

Sinnissippi Centers Inc
+1 photos

Sinnissippi Centers Inc

Freeport, IL

Sinnissippi Centers Inc, located in Freeport, IL, is dedicated to providing comprehensive substance use treatment alongside specialized care for those dealing with both substance use issues and serious mental health challenges. This facility offers a range of treatment options, including intensive outpatient programs and outpatient services featuring methadone, buprenorphine, or naltrexone therapies. With an emphasis on 12-step facilitation, anger management, and brief intervention techniques, the center supports a diverse group of clients, such as active duty military members, adolescents, and adult men. Sinnissippi Centers Inc proudly serves adults and seniors of any gender, ensuring they receive high-quality, gender-specific care that meets their individual needs.

Damascus House
+1 photos

Damascus House

Brooklyn, MD

Situated in Brooklyn, MD, Damascus House provides a wide array of rehabilitation services designed specifically for adult men. This facility excels in substance abuse treatment, as well as offering transitional housing and sober living programs. They offer various treatment formats such as intensive outpatient, long-term residential, and outpatient options to meet the diverse needs of their clients. Their approach incorporates methods like 12-step facilitation, anger management, and brief intervention techniques. Additionally, Damascus House features specialized programs that address the unique challenges faced by adult men who have encountered intimate partner violence, domestic violence, and sexual abuse. Catering to adults, seniors, and young adults, the facility is committed to delivering high-quality care that empowers male clients on their path to recovery.

Groups Recover Together
+1 photos

Groups Recover Together

Martinsville, IN

Groups Recover Together, located in Martinsville, IN, offers outpatient treatment for both adults and young adults struggling with substance use issues. The facility provides a range of services, including outpatient methadone or buprenorphine therapy, naltrexone treatment, regular outpatient care, and telemedicine therapy. Their primary focus is on preventing relapse and delivering personalized counseling for substance use disorders. With a tailored approach for each individual, this center serves clients of all genders, ensuring that everyone receives the support they need. At Groups Recover Together, clients can anticipate high-quality care in a welcoming environment that fosters recovery. What sets them apart is their dedication to offering a variety of comprehensive treatment options and their commitment to effective, personalized addiction recovery solutions.

Baden Street Settlement
+1 photos

Baden Street Settlement

Rochester, NY

Baden Street Settlement, situated in Rochester, NY, stands out as a respected rehabilitation center dedicated to helping adults and young adults recover from substance use disorders. The facility offers outpatient services that include treatments with methadone, buprenorphine, or naltrexone. Their approach is centered on individualized care, utilizing methods such as cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies. By focusing on customization, Baden Street Settlement meets the unique needs of both male and female clients on their path to recovery. If you’re in search of well-rounded, personalized support in a nurturing atmosphere, this center is devoted to assisting you on your journey to successful rehabilitation.

Detox Center II
+1 photos

Detox Center II

Boca Raton, FL

Located in Boca Raton, FL, Detox Center II provides extensive detoxification and substance use treatment tailored for adults and young adults dealing with serious co-occurring mental health issues. The facility offers several options, including residential detox, around-the-clock residential care, and short-term residential programs. By employing methods such as 12-step facilitation, anger management, and brief intervention, the center serves both adult men and women, as well as active duty military personnel. Detox Center II also features specialized programs aimed at different age groups and genders, ensuring that each person receives personalized care. With a strong emphasis on quality treatment and a variety of unique options, this center stands out as a premier choice for anyone looking for effective rehabilitation services.

Family Support Center
+1 photos

Family Support Center

Winnemucca, NV

The Family Support Center, based in Winnemucca, NV, specializes in outpatient treatment for adults grappling with substance use and co-occurring mental health disorders, as well as for children facing emotional challenges. Utilizing techniques such as brief intervention, cognitive behavioral therapy, and motivational interviewing, this facility offers tailored programs designed for adolescents, adult men, and adult women. With a strong emphasis on delivering high-quality care, the center serves individuals of all genders, including both adults and children/adolescents. Its commitment to a comprehensive approach to recovery makes the Family Support Center a standout option for anyone in search of effective and personalized addiction treatment.

New Opportunities Inc
+1 photos

New Opportunities Inc

Sac City, IA

Situated in Sac City, IA, New Opportunities Inc provides tailored substance use treatment programs serving adults, children, and adolescents. The center features a variety of services, including intensive outpatient treatment, regular outpatient care, and brief intervention options. With a commitment to delivering high-quality care, the facility employs evidence-based strategies like contingency management/motivational incentives and the Matrix Model. One standout aspect of this center is its dedicated program designed specifically for adolescents, which addresses their unique needs. New Opportunities Inc welcomes both male and female clients, fostering an inclusive and comprehensive environment for addiction treatment.

Aurora Behavioral Health Center
+1 photos

Aurora Behavioral Health Center

Sheboygan, WI

Situated in Sheboygan, WI, Aurora Behavioral Health Center provides a wide range of treatment options for individuals dealing with substance use and co-occurring mental health issues, whether they're adults or children. The center offers various programs, including intensive outpatient, outpatient, and partial hospitalization services, incorporating techniques like anger management, cognitive behavioral therapy, and brief interventions. With a strong emphasis on personalized care, Aurora Behavioral Health Center serves both male and female adults as well as young adults in search of effective and individualized rehabilitation solutions. Discover quality care and customized treatment plans at this facility, where a comprehensive approach to recovery is prioritized.

Counseling First
+1 photos

Counseling First

Chicago, IL

Counseling First, situated in Chicago, IL, offers outpatient treatment for substance use tailored for both adults and young adults. This center excels in techniques such as 12-step facilitation, anger management, and brief intervention methods. They pay special attention to criminal justice and forensic clients, providing dedicated support for those connected to the legal system. With services available for both men and women, Counseling First fosters an inclusive and comprehensive approach to treatment. Their dedication to high-quality care and customized programs positions them as an essential resource for anyone in the Chicago area looking for effective and personalized help with addiction.

Willamette Family Treatment Servs
+1 photos

Willamette Family Treatment Servs

Eugene, OR

Willamette Family Treatment Services, located in Eugene, OR, is a dedicated rehabilitation center focused on helping adult women tackle substance use issues. The facility provides a variety of treatment options, including intensive outpatient programs, long-term residential care, and standard outpatient services. Emphasizing 12-step facilitation, anger management, and brief interventions, Willamette Family Treatment Services is well-equipped to assist clients who have faced intimate partner violence, domestic violence, and trauma. Catering to adults, seniors, and young adults alike, this center ensures a safe and nurturing space for female clients as they work towards overcoming addiction and rebuilding their lives.

Arthur Center Community Health
+1 photos

Arthur Center Community Health

Montgomery City, MO

Nestled in Montgomery City, MO, the Arthur Center Community Health provides a wide range of outpatient treatment options for substance use, catering specifically to adults and seniors. This facility stands out for its personalized programs designed to meet the unique needs of every individual, offering a welcoming environment for both men and women on their path to recovery. Their treatment strategy integrates outpatient methadone, buprenorphine, or naltrexone therapy with ongoing outpatient services, ensuring a comprehensive and effective approach to healing. Renowned for delivering high-quality care with an individualized focus, the Arthur Center Community Health has become a reliable option for those aiming to overcome addiction and take control of their lives once again.

Adept Assessment Center
+1 photos

Adept Assessment Center

Deer Park, WA

Located in Deer Park, WA, Adept Assessment Center specializes in providing substance use treatment for both adults and seniors. They offer a variety of program options, including intensive outpatient, outpatient, and regular outpatient services. The center employs various techniques, such as 12-step facilitation, anger management, and brief intervention, to deliver personalized care that caters to each individual's needs. With programs available for both men and women, the center fosters a welcoming and supportive atmosphere for all clients. Adept Assessment Center is dedicated to delivering high-quality care and tailored treatment, making it a great choice for anyone in the Deer Park area looking for effective and comprehensive addiction rehabilitation services.

Sol Medical Group
+1 photos

Sol Medical Group

Durham, NC

Located in Durham, NC, Sol Medical Group specializes in outpatient treatment for both substance use and co-occurring mental health disorders in individuals of all ages, including adults and children. The center offers a range of treatment options, such as outpatient methadone, buprenorphine, or naltrexone programs. Emphasizing brief intervention, community reinforcement, and relapse prevention, Sol Medical Group customizes its care to meet the unique needs of each patient. The facility provides distinct programs designed for adolescents, as well as adult men and women, ensuring that services are accessible for adults and seniors of any gender. With a strong commitment to high-quality care and personalized approaches, Sol Medical Group serves as an essential resource for those in need of comprehensive rehabilitation services in the Durham community.

Micah House
+1 photos

Micah House

Minneapolis, MN

Micah House, situated in Minneapolis, MN, provides a wide array of treatment services designed to address substance use disorders and co-occurring mental health challenges for both adults and children. The facility features various programs, including intensive outpatient care, long-term residential support, and standard outpatient options. Their approach integrates 12-step facilitation, cognitive-behavioral therapy, and anger management to support recovery. Additionally, they offer specialized programs aimed at adult men and women, as well as those who have faced intimate partner or domestic violence. With a commitment to quality care, Micah House welcomes individuals of all genders, fostering a compassionate environment for those in search of effective rehabilitation solutions.

TLCS Inc
+1 photos

TLCS Inc

Sacramento, CA

Located in Sacramento, CA, TLCS Inc specializes in outpatient substance use treatment, offering targeted care for adults dealing with co-occurring substance use and serious mental health issues, as well as addressing emotional disturbances in children. Their regular outpatient services incorporate evidence-based methods, including anger management, brief intervention, and cognitive behavioral therapy. The facility serves adult men and women, particularly those who have faced intimate partner or domestic violence. With customized programs designed for adults and young adults across genders, TLCS Inc is dedicated to providing thorough and compassionate support for individuals on their journey toward recovery and healing from addiction and mental health challenges.

Lexington Treatment Associates
+1 photos

Lexington Treatment Associates

Lexington, NC

Situated in Lexington, NC, Lexington Treatment Associates specializes in outpatient substance use treatment for both adults and young adults. The center offers a range of services, including outpatient treatments with methadone, buprenorphine, or naltrexone. Their approach emphasizes motivational interviewing, relapse prevention, and counseling specifically for substance use disorders. Notably, the facility prioritizes individualized care, accommodating both male and female clients. Lexington Treatment Associates is recognized for its personalized approach to addiction treatment, providing quality support to help individuals on their path to recovery.

Addiction Research and Treatment Inc
+1 photos

Addiction Research and Treatment Inc

Porterville, CA

Addiction Research and Treatment Inc, situated in Porterville, CA, provides a range of outpatient services designed for those looking to overcome substance use disorders. The facility excels in detoxification, substance use treatment, and addressing co-occurring mental health conditions for both adults and children. Placing significant emphasis on cognitive behavioral therapy, motivational interviewing, and relapse prevention, the center crafts personalized treatment plans to foster long-lasting sobriety. Additionally, it offers specialized programs for active duty military personnel, as well as tailored services for adult men and women. Catering to adults and young adults of every gender, Addiction Research and Treatment Inc is committed to delivering high-quality care and unwavering support throughout the recovery journey.

Safe Refuge
+1 photos

Safe Refuge

Long Beach, CA

Nestled in Long Beach, CA, Safe Refuge provides a wide array of rehabilitation services tailored to meet diverse needs. This center specializes in treating substance use issues and also offers transitional housing and sober living options. Additionally, it addresses co-occurring substance use and serious mental health conditions for adults, as well as emotional disturbances in children. At Safe Refuge, you’ll find various treatment formats, including intensive outpatient care, long-term residential stays, and outpatient programs. The center is equipped with evidence-based strategies such as 12-step facilitation, anger management, and cognitive behavioral therapy. With dedicated programs for active-duty military personnel and for both adult men and women, Safe Refuge is committed to catering to a broad spectrum of individuals. Whether for adults or young adults of any gender, the facility aims to deliver exceptional care and support to those on their path to recovery.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab