Penn Spine and Rehab Logo

Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

Need Help Finding the Right Treatment?

Browse our directory or call to discuss treatment options.

Call 1(223) 235-7839
12,000+ Centers
SAMHSA Data
Filters:

Showing 20 of 8160 depression rehab centers

Vitality Integrated Programs
+1 photos

Vitality Integrated Programs

Reno, NV

Located in Reno, NV, Vitality Integrated Programs offers a wide range of substance use treatment options designed for adults facing serious mental health challenges, as well as for children dealing with significant emotional disturbances. The facility prides itself on providing intensive outpatient, outpatient, and day treatment services that include anger management, brief interventions, and cognitive behavioral therapy. There are specialized programs available for individuals who have experienced intimacy-related violence, sexual abuse, or trauma. Catering to both male and female clients, Vitality Integrated Programs emphasizes high-quality, personalized care aimed at promoting lasting recovery and emotional health. By focusing on customized treatment plans and evidence-based methods, this facility effectively supports both adults and children on their journey to comprehensive rehabilitation.

Mental Health Cooperative Inc
+1 photos

Mental Health Cooperative Inc

Murfreesboro, TN

Situated in Murfreesboro, TN, Mental Health Cooperative Inc specializes in outpatient treatment for substance use and co-occurring disorders, catering to both adults and children. The center offers a range of services, including outpatient methadone/buprenorphine or naltrexone treatment, as well as standard outpatient care. They use evidence-based methods such as cognitive behavioral therapy and motivational interviewing to ensure effective support. With a commitment to personalized care, this facility adjusts its treatment plans to address the specific needs of every client. Mental Health Cooperative Inc is dedicated to providing high-quality care and comprehensive programs aimed at fostering recovery and enhancing overall well-being for adults and seniors of all genders.

Counseling Center of Illinois Inc
+1 photos

Counseling Center of Illinois Inc

Chicago, IL

The Counseling Center of Illinois Inc, situated in Chicago, IL, provides a wide array of substance use treatment programs designed to meet varying needs. They offer intensive outpatient treatment along with outpatient and regular outpatient services specifically created for adults and young adults. With key focuses on anger management, brief interventions, and cognitive behavioral therapy, the center addresses the needs of both men and women. Additionally, they present specialized programs for active duty military personnel as well as distinct options for adult men and women, which further enhances the care provided. If you or someone you know is in need of targeted addiction treatment, this facility utilizes a variety of evidence-based methods to support the path towards recovery.

Genesee Council On Alc/Subst Abuse
+1 photos

Genesee Council On Alc/Subst Abuse

Batavia, NY

Located in Batavia, NY, the Genesee Council on Alcohol/Substance Abuse provides outpatient treatment for substance use, along with specialized care tailored for adults facing serious co-occurring mental health conditions. Their programs include anger management, cognitive behavioral therapy, and brief interventions that address various needs. The facility emphasizes personalized care with programs specifically designed for adolescents, adult men, and women. They offer services to a diverse range of individuals, including adults, children and adolescents, as well as seniors, with dedicated programs for both males and females. Furthermore, the center provides outpatient treatment options using methadone, buprenorphine, or naltrexone, alongside regular outpatient services. This comprehensive approach ensures that individuals seeking recovery receive the support they need.

Echo House Multi Service Center Inc
+1 photos

Echo House Multi Service Center Inc

Baltimore, MD

Nestled in Baltimore, MD, Echo House Multi Service Center Inc is dedicated to offering a variety of addiction treatment services. The center specializes in detoxification and substance use treatment, providing options such as intensive outpatient programs, outpatient services, and outpatient detoxification. Their approach is grounded in evidence-based practices, incorporating techniques like cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies. Echo House Multi Service Center also features tailored programs designed for adult men, adult women, and young adults, ensuring that individuals from different age groups and genders receive personalized support. With a strong commitment to delivering high-quality care, this facility stands out as an excellent option for those in search of comprehensive and effective addiction treatment services.

Moore Youth And Family Services Inc
+1 photos

Moore Youth And Family Services Inc

Oklahoma City, OK

Moore Youth And Family Services Inc, situated in Oklahoma City, OK, provides outpatient treatment for adults dealing with substance use issues alongside serious mental health concerns, as well as for children facing significant emotional disturbances. The center is well-versed in anger management, cognitive behavioral therapy, and motivational interviewing techniques. With a special emphasis on adolescents, they offer customized programs catering to both adults and children of all genders. Committed to delivering high-quality support, Moore Youth And Family Services Inc strives to help individuals navigate their substance use and mental health challenges with effective and comprehensive care.

Northeast LA Substance Abuse Inc
+1 photos

Northeast LA Substance Abuse Inc

Winnsboro, LA

Situated in Winnsboro, LA, Northeast LA Substance Abuse Inc is dedicated to offering specialized treatment programs for substance use that address the needs of different age groups and genders. The facility features options like intensive outpatient treatment and outpatient services, along with specialized outpatient care involving methadone, buprenorphine, or naltrexone. Emphasizing a holistic approach, the center incorporates 12-step facilitation, anger management, and brief intervention techniques into its programs. Importantly, they provide tailored services for active duty military personnel, adolescents, and adult men. Northeast LA Substance Abuse Inc is committed to delivering quality care for a diverse clientele, including adults, children, and seniors, with distinct programs designed to cater to the specific needs of both male and female participants.

Evexia Health Services
+1 photos

Evexia Health Services

Hemet, CA

Evexia Health Services, located in Hemet, CA, provides outpatient detoxification and treatment programs specifically designed for adults and seniors. This facility prides itself on offering specialized support for pregnant and postpartum women, recognizing the distinct challenges they may face during recovery. At Evexia, the focus is on personalized care, featuring services such as anger management, cognitive behavioral therapy, and motivational incentives to create tailored treatment plans. Additionally, the center provides outpatient options for methadone, buprenorphine, or naltrexone treatment. Welcoming both male and female clients, Evexia Health Services is committed to delivering high-quality care and support for anyone on their journey to sobriety.

Big Island Substance Abuse Council
+1 photos

Big Island Substance Abuse Council

Hilo, HI

The Big Island Substance Abuse Council, situated in Hilo, HI, specializes in providing effective substance use treatment and transitional housing specifically for women. They prioritize long-term residential care and offer round-the-clock support alongside tailored programs for pregnant and postpartum women. By incorporating techniques such as 12-step facilitation and anger management, the center serves both adults and seniors who are on their journey toward full addiction recovery. Their approach emphasizes brief intervention, ensuring that young adults receive the personalized care they need. With a focus on creating a nurturing environment and offering gender-specific services, this facility is committed to empowering women to reach sustainable sobriety and holistic wellness.

Counseling Center of Illinois Inc
+1 photos

Counseling Center of Illinois Inc

Palos Hills, IL

Situated in Palos Hills, IL, the Counseling Center of Illinois Inc provides a wide range of substance use treatment options. They offer intensive outpatient, outpatient, and regular outpatient programs. The center has a particular focus on anger management, brief interventions, and cognitive behavioral therapy. Tailored programs are available specifically for active duty military members, as well as adult men and women. This facility caters to both adults and young adults, regardless of gender. With a commitment to quality care that emphasizes individualized treatment, the Counseling Center of Illinois Inc is dedicated to supporting individuals as they work towards recovery from addiction.

Oxytocin LLC
+1 photos

Oxytocin LLC

Kalispell, MT

Located in Kalispell, MT, Oxytocin LLC offers a variety of comprehensive rehabilitation services specifically designed for individuals facing substance use disorders alongside co-occurring mental health challenges. The center features several treatment options, including intensive outpatient treatment, outpatient day programs, and partial hospitalization. Their methods encompass anger management, cognitive behavioral therapy, and brief interventions, catering to both adult men and women, including those who have experienced intimate partner or domestic violence. Oxytocin LLC emphasizes a tailored approach, providing specialized care for adults and young adults of all genders. If you’re looking for a supportive environment that prioritizes personalized and effective addiction treatment, this facility is committed to guiding you on your journey towards recovery.

Spero Health
+1 photos

Spero Health

Danville, VA

Situated in Danville, VA, Spero Health specializes in outpatient treatments for substance use, catering to adult men, women, and young adults. The center has tailored programs specifically designed for those who have faced intimate partner violence or domestic violence. Their treatment methods incorporate anger management, brief intervention techniques, and cognitive behavioral therapy. In addition, Spero Health provides outpatient services for methadone, buprenorphine, and naltrexone, alongside standard outpatient care. Committed to delivering high-quality support and personalized treatment plans, this facility aims to assist individuals in conquering addiction and attaining long-term recovery.

Southern CA Alcohol and Drug Prog Inc
+1 photos

Southern CA Alcohol and Drug Prog Inc

Bellflower, CA

Southern CA Alcohol and Drug Prog Inc, located in Bellflower, CA, delivers a wide range of addiction treatment services specifically designed for female adults, seniors, and young adults. The facility excels in detoxification, substance use treatment, and dual diagnosis care for those experiencing both substance use issues and serious mental health conditions. They offer long-term residential programs, residential detoxification, and 24-hour residential care. With an emphasis on 12-step facilitation, anger management, and brief intervention methods, the center customizes its treatment plans to address each individual's unique needs. Additionally, they provide specialized programs for adult women, as well as for survivors of intimate partner violence, domestic violence, and sexual abuse, creating a nurturing environment for healing. At Southern CA Alcohol and Drug Prog Inc, you can expect compassionate care backed by evidence-based treatment.

SAFE Foundation Inc
+1 photos

SAFE Foundation Inc

Brooklyn, NY

Located in Brooklyn, NY, SAFE Foundation Inc provides outpatient substance use treatment programs tailored for adults and seniors. The center is equipped to deliver specialized care for adult men, adult women, and young adults, addressing the needs of various age groups and genders. Utilizing treatment methods such as 12-step facilitation, brief interventions, and cognitive behavioral therapy, they focus on delivering personalized care to each individual. Their offerings include outpatient treatment with methadone, buprenorphine, or naltrexone, as well as regular outpatient options, making the journey to recovery more accessible. The dedication of SAFE Foundation Inc to high-quality care and a range of program choices makes it a significant resource for those in search of effective addiction treatment in Brooklyn.

Mission City Community Network
+1 photos

Mission City Community Network

North Hills, CA

Located in North Hills, CA, Mission City Community Network offers outpatient treatment for substance use, along with specialized support for adults dealing with serious mental health issues or children facing significant emotional disturbances. The center features outpatient options for methadone, buprenorphine, and naltrexone, in addition to standard outpatient services. With a strong emphasis on 12-step facilitation, anger management, and brief intervention techniques, the facility supports a diverse range of individuals, including active military personnel, adolescents, and adult men. Mission City Community Network is dedicated to providing effective, personalized care for both adults and children/adolescents of all genders, ensuring that each person's unique needs are addressed.

Sound
+1 photos

Sound

Seattle, WA

Situated in Seattle, WA, "Sound" delivers a wide range of substance use treatment options for adults, particularly those dealing with serious mental health issues or emotional challenges in children. The center offers intensive outpatient programs alongside various outpatient services, including targeted treatments with methadone, buprenorphine, or naltrexone. By incorporating effective techniques such as brief intervention, cognitive behavioral therapy, and the Matrix Model, "Sound" personalizes its treatment strategies to meet the unique needs of each individual. What truly sets "Sound" apart is its focus on offering tailored care for both adults and young adults, with specialized programs available for each gender. Committed to delivering quality, individualized treatment, "Sound" fosters a supportive atmosphere for anyone on their path to recovery from addiction.

UConnectCare
+1 photos

UConnectCare

Batavia, NY

UConnectCare, situated in Batavia, NY, specializes in providing thorough detoxification and substance use treatment programs. The center offers residential detox services along with 24/7 residential support for both adults and young adults. By employing methods such as brief intervention, cognitive behavioral therapy, and motivational interviewing, UConnectCare ensures that treatment plans are customized to meet the unique needs of each person. With a strong emphasis on personalized care, the facility features distinct programs designed for both male and female clients. Patients can look forward to receiving high-quality, evidence-based care in a nurturing environment. If you’re on the lookout for effective addiction treatment that emphasizes individual attention, UConnectCare might just be the right choice for your path to recovery.

Malama Na Makua A Keiki
+1 photos

Malama Na Makua A Keiki

Kahului, HI

Malama Na Makua A Keiki, situated in Kahului, HI, specializes in a range of substance use treatment options, emphasizing intensive outpatient care, long-term residential services, and outpatient programs. The facility employs evidence-based practices, including cognitive behavioral therapy, the Matrix Model, and motivational interviewing. It features tailored programs designed specifically for adult women, pregnant or postpartum women, and young adults. This center exclusively serves females, focusing on adults, seniors, and young adults seeking help. With a strong commitment to delivering quality care and developing personalized treatment plans, Malama Na Makua A Keiki strives to create a supportive atmosphere for individuals on their path to recovery from substance use disorders.

Carpe Diem Behavioral Associates Inc
+1 photos

Carpe Diem Behavioral Associates Inc

Saco, ME

Carpe Diem Behavioral Associates Inc, located in Saco, ME, specializes in outpatient substance use treatment for both adults and young adults. The center offers regular outpatient services employing various strategies, including 12-step facilitation, anger management, and brief interventions. With tailored programs for active duty military personnel, as well as for adult men and women, this facility addresses a wide range of needs. Committed to providing high-quality care, Carpe Diem serves both females and males, focusing on support as individuals embark on their recovery journey. If you're looking for personalized and impactful addiction treatment, this center is dedicated to helping you create lasting change.

Near North Health Service Corporation
+1 photos

Near North Health Service Corporation

Chicago, IL

Located in Chicago, IL, Near North Health Service Corporation specializes in outpatient treatment for substance use disorders, particularly for adults facing co-occurring substance use and serious mental health challenges, as well as children dealing with emotional disturbances. Their range of programs includes anger management, brief interventions, and cognitive behavioral therapy. This facility is dedicated to providing tailored services for adult men and women, including those who have experienced domestic or intimate partner violence. Near North Health Service Corporation prioritizes the needs of both adult and young adult clients, offering quality care through outpatient treatment options such as methadone, buprenorphine, or naltrexone, along with standard outpatient services.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab