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Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

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Showing 20 of 8160 depression rehab centers

Ascension Eastwood Behavioral Health

Ascension Eastwood Behavioral Health

Livonia, MI

Located in Livonia, MI, Ascension Eastwood Behavioral Health specializes in outpatient services for substance use treatment, as well as offering specialized care for adults dealing with co-occurring substance use and severe mental health issues, and for children experiencing serious emotional disturbances. Their evidence-based methods encompass brief interventions, cognitive behavioral therapy, and motivational interviewing. With a strong emphasis on personalized care, the center accommodates adults and children/adolescents of all genders. Ascension Eastwood Behavioral Health creates a nurturing environment, allowing clients to receive high-quality treatment that is tailored to their specific needs, promoting enduring recovery and overall well-being.

Rosecrance Inc

Rosecrance Inc

La Grange, IL

Situated in La Grange, IL, Rosecrance Inc provides a wide range of substance use treatment programs designed for adults, children, and adolescents alike. The facility offers various treatment options, including intensive outpatient, outpatient, and regular outpatient programs, all tailored to meet the unique needs of each individual. With a strong emphasis on relapse prevention and counseling for substance use disorders, the center also incorporates telemedicine and telehealth therapy to enhance accessibility. For adolescents and young adults, Rosecrance Inc has specialized programs that ensure care is appropriate for their age group. Committed to serving both male and female clients, the center focuses on delivering high-quality, gender-specific treatment that fosters lasting recovery.

Stigler Health and Wellness Inc

Stigler Health and Wellness Inc

McAlester, OK

Stigler Health and Wellness Inc, located in McAlester, OK, provides a wide range of addiction treatment services designed for adults and seniors. This facility offers detoxification, substance use treatment, transitional housing, and sober living alternatives. Clients have the flexibility to choose from intensive outpatient programs, long-term residential care, or outpatient treatment formats. With an emphasis on brief intervention, cognitive behavioral therapy, and community reinforcement as well as vouchers, Stigler Health and Wellness Inc customizes its programs to meet the unique needs of each individual. The center also features specialized programs for adolescents, adult men, and adult women. Committed to delivering quality care, Stigler Health and Wellness Inc provides gender-specific treatment options for both males and females.

Remedies Renewing Lives

Remedies Renewing Lives

Belvidere, IL

Situated in Belvidere, IL, Remedies Renewing Lives specializes in a variety of substance use treatment programs specifically designed for adult men and women. The facility offers a spectrum of options, including intensive outpatient treatment, general outpatient services, and regular outpatient care. By employing evidence-based methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy, the center effectively supports clients who have faced intimate partner or domestic violence. Catering to both adults and young adults, Remedies Renewing Lives prioritizes personalized care to enhance the recovery experience. With an emphasis on quality and tailored programs, this facility truly serves as a guiding light for individuals in search of comprehensive addiction treatment.

Family Guidance Centers Inc

Family Guidance Centers Inc

Des Plaines, IL

Family Guidance Centers Inc, located in Des Plaines, IL, specializes in outpatient substance use treatment for adults who are facing serious mental health challenges, alongside providing support for children with significant emotional disturbances. The center offers outpatient options including methadone, buprenorphine, or naltrexone treatment, in addition to standard outpatient care. By incorporating techniques such as cognitive behavioral therapy, motivational interviewing, and relapse prevention, the program is designed to fit the unique needs of each individual. Catering to adults and young adults of all genders, this facility is recognized for its tailored approach and dedication to helping clients find a path to lasting recovery.

Cascade Community Healthcare

Cascade Community Healthcare

Chehalis, WA

Cascade Community Healthcare, located in Chehalis, WA, provides a wide array of addiction treatment services for both adults and children. The center excels in areas such as detoxification, substance use treatment, and addressing co-occurring disorders. With offerings that include intensive outpatient and outpatient programs, the facility also specializes in outpatient detoxification. Their approach focuses on brief interventions, cognitive behavioral therapy, and community reinforcement, making it a supportive environment for clients dealing with dual challenges of pain and substance use disorders. Cascade Community Healthcare is inclusive, welcoming both male and female clients and ensuring that each individual receives personalized care. Here, you can expect quality treatment rooted in evidence-based methods, all aimed at helping individuals embark on a path toward lasting recovery.

New York Therapeutic Communities Inc

New York Therapeutic Communities Inc

Jamaica, NY

New York Therapeutic Communities Inc, situated in Jamaica, NY, specializes in substance use treatment programs designed for both adults and adolescents. The facility offers a variety of treatment options, including intensive outpatient, outpatient, and regular outpatient programs. With an emphasis on 12-step facilitation, anger management, and brief intervention methods, the center tailors its approach to meet the specific needs of each individual. They provide specialized programs for active duty military personnel, adolescents, and adult men. The center serves both male and female clients, ensuring that individuals of all ages receive high-quality care. New York Therapeutic Communities Inc is committed to delivering effective and comprehensive rehabilitation services for those on their journey to recovery from substance use disorders.

Hogar Crea Las Marias

Hogar Crea Las Marias

Las Marias, PR

Hogar Crea Las Marias, situated in Las Marias, PR, is a distinguished rehabilitation center that specializes in treating substance use issues among adult men. The center offers a wide range of comprehensive programs designed for those facing both substance use and serious mental health challenges. Their methods are grounded in evidence-based practices, which include cognitive behavioral therapy and relapse prevention strategies. Prioritizing high-quality care, Hogar Crea provides various treatment options, such as hospital inpatient services, 24-hour inpatient care, and long-term residential programs. They also have specialized initiatives tailored to meet the needs of adult men as well as clients involved with the criminal justice system. This facility caters to a diverse clientele, including adults, seniors, and young adults, all aimed at supporting individuals on their journey towards lasting recovery and enhanced well-being.

DREAM Provider Care Services

DREAM Provider Care Services

Plymouth, NC

DREAM Provider Care Services, located in Plymouth, NC, offers a thorough range of outpatient treatments designed for those struggling with substance use and co-occurring mental health disorders. The facility has a particular focus on supporting adults facing serious mental health challenges and children dealing with emotional disturbances. Among the services provided are 12-step facilitation, anger management, and cognitive behavioral therapy. The center features specialized programs aimed at active duty military personnel, adolescents, and adult men, ensuring that support is specifically tailored to meet these unique needs. With a commitment to serving adults and seniors of all genders, including distinct programs for both women and men, DREAM Provider Care Services is dedicated to delivering high-quality care in a nurturing environment. Whether individuals are looking for outpatient treatment, methadone/buprenorphine/naltrexone therapies, or standard outpatient services, they can expect to receive personalized treatment plans crafted to their specific needs at this facility.

Egyptian Public and Mental Health Dept

Egyptian Public and Mental Health Dept

Harrisburg, IL

Located in Harrisburg, IL, the Egyptian Public and Mental Health Department specializes in outpatient treatment for both substance use disorders and co-occurring mental health conditions in adults and children. The facility employs a range of strategies including 12-step facilitation, anger management, and brief intervention, all designed to provide personalized care that caters to individual needs. They offer unique programs specifically for active duty military personnel, adolescents, and adult men, ensuring that support is tailored for different groups. The center serves clients of all ages, both male and female, with a strong focus on delivering high-quality care grounded in evidence-based practices. For those in search of comprehensive and reliable rehabilitation services, the Egyptian Public and Mental Health Dept stands out as a trusted option in Harrisburg.

CMI Heathcare Services

CMI Heathcare Services

Memphis, TN

Located in Memphis, TN, CMI Healthcare Services specializes in treating adult women grappling with substance use and serious mental health challenges. The facility offers a range of programs, including intensive outpatient, long-term residential, and outpatient options, all designed to cater to individual needs. Their approach combines 12-step facilitation, anger management, and brief intervention strategies to ensure well-rounded care for each patient. Notably, they also provide tailored programs for pregnant and postpartum women, reflecting their dedication to serving a diverse population. CMI Healthcare Services is committed to delivering high-quality care to adults, seniors, and young adults in a welcoming atmosphere. If you're looking for personalized treatment in a supportive environment, this facility is here to assist you on your recovery journey.

Self Help Addiction Rehab (SHAR)

Self Help Addiction Rehab (SHAR)

Detroit, MI

Self Help Addiction Rehab (SHAR) located in Detroit, MI, delivers a wide array of addiction treatment services designed specifically for adults and young adults. The center offers specialized programs catering to adult men, women, and clients who have faced trauma. Among the options available are long-term residential stays, outpatient programs, and transitional housing. SHAR employs various methods including 12-step facilitation, anger management, and brief intervention, all aimed at providing personalized care and support to each individual. Additionally, for those requiring assistance, the facility provides outpatient treatments using methadone, buprenorphine, or naltrexone. With a strong emphasis on quality care and a gender-specific approach, SHAR creates a nurturing atmosphere for individuals working to overcome substance use disorders.

Mid Atlantic Rehabilitation Services

Mid Atlantic Rehabilitation Services

Bethlehem, PA

Mid Atlantic Rehabilitation Services, located in Bethlehem, PA, is dedicated to offering specialized treatment for both substance use and co-occurring mental health challenges in adults and children alike. The center provides a range of options, including intensive outpatient and outpatient programs, with an emphasis on 12-step facilitation, anger management, and brief intervention techniques. They also have customized programs designed specifically for adolescents, as well as adult men and women, ensuring that each person's care is tailored to their needs. This facility proudly serves individuals of all genders, from children to adults, with a strong commitment to delivering high-quality care grounded in evidence-based practices. Whether you're looking for intensive day treatment or outpatient support, Mid Atlantic Rehabilitation Services offers a comprehensive array of services to help individuals on their path to recovery.

Tempo Group Inc

Tempo Group Inc

Syosset, NY

Tempo Group Inc, located in Syosset, NY, provides a wide range of substance use treatment options through its various outpatient programs. These include outpatient methadone, buprenorphine, or naltrexone treatments, along with regular outpatient therapy and 12-step facilitation. This facility emphasizes a blend of 12-step support, anger management, and brief intervention strategies, and it offers specialized programs tailored for adolescents, adult men, and adult women. Tempo Group Inc caters to both adults and youth, ensuring that both male and female clients receive the high-quality addiction treatment they seek. If you're in search of personalized and effective substance use treatment within a caring environment, this center could be the ideal place to support your recovery journey.

Central Florida Treatment Center

Central Florida Treatment Center

Titusville, FL

Central Florida Treatment Center, located in Titusville, FL, provides outpatient detoxification and treatment programs for both adults and young adults struggling with substance use. The center places a strong emphasis on supporting pregnant and postpartum women, offering personalized care options for individuals of all genders. Their programs incorporate essential techniques such as 12-step facilitation, anger management, and brief intervention strategies, ensuring that those on the path to recovery receive well-rounded support. Committed to delivering high-quality care and customized treatment plans, this facility serves as a guiding light for anyone seeking to overcome addiction. If you or someone you care about is in search of compassionate and effective treatment for addiction, think about Central Florida Treatment Center as a reliable ally on the road to recovery.

RiverValley Behavioral Health

RiverValley Behavioral Health

Providence, KY

RiverValley Behavioral Health, located in Providence, KY, provides outpatient treatment for substance use as well as specialized care for those facing both substance use issues and serious mental health conditions. The center emphasizes techniques like 12-step facilitation, anger management, and brief intervention strategies, offering customized programs for active duty military members, adolescents, and adult men. Catering to adults and seniors of all genders, this facility is dedicated to delivering high-quality care in a nurturing atmosphere. Clients looking for support with either substance use concerns or co-occurring disorders can anticipate a broad range of services aimed at fostering lasting recovery and enhancing their overall mental health.

Rushford at Avon

Rushford at Avon

Avon, CT

Situated in Avon, CT, Rushford at Avon specializes in treating substance use issues alongside co-occurring mental health disorders for both adults and children. The facility focuses on intensive outpatient and outpatient programs, offering a variety of therapeutic methods such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. To ensure personalized care, they provide tailored programs for adult men, adult women, and those who have experienced trauma. Catering to adults and young adults of all genders, Rushford at Avon creates a supportive and welcoming environment. If you or someone you care about is looking for evidence-based treatment delivered with compassion, this center is dedicated to providing high-quality care to help facilitate lasting recovery.

Shreveport Behavioral Health Clinic

Shreveport Behavioral Health Clinic

Shreveport, LA

Situated in Shreveport, LA, the Shreveport Behavioral Health Clinic specializes in treating adults dealing with substance use disorders alongside serious mental health challenges. This facility offers a range of services including intensive outpatient programs, outpatient services, and outpatient treatment options involving methadone/buprenorphine or naltrexone. Emphasizing approaches like 12-step facilitation, cognitive behavioral therapy, and the Matrix Model, the clinic customizes treatments to meet the unique needs of each individual. Additionally, there are specialized programs designed for active duty military members, adolescents, and adult men. Catering to adults and seniors of all genders, the clinic prioritizes quality care through gender-specific programs and a personalized treatment approach.

Alcohol Information and Counseling Ctr

Alcohol Information and Counseling Ctr

Lapeer, MI

Situated in Lapeer, MI, the Alcohol Information and Counseling Center provides extensive substance use treatment for both adults and adolescents. This facility offers a range of programs including intensive outpatient, outpatient, and regular outpatient treatment. By employing methods like anger management, brief intervention, and cognitive behavioral therapy, the center serves clients of all genders. There are also specialized programs tailored for adult men, adult women, and adolescents. With an emphasis on high-quality care and personalized treatment plans, this center stands as a vital resource for individuals in the Lapeer community who are seeking effective addiction rehabilitation services.

Mercy Hall

Mercy Hall

Freeport, NY

Located in Freeport, NY, Mercy Hall provides extensive long-term residential treatment for adults dealing with substance use and co-occurring mental health concerns. This facility is particularly focused on creating a supportive atmosphere for adult women, seniors, and young adults who have faced intimate partner violence. Additionally, they also serve active duty military personnel. At Mercy Hall, the treatment approach emphasizes 12-step facilitation, anger management, and brief intervention strategies, ensuring high-quality care in a secure and nurturing environment. Clients have access to transitional housing options along with specialized programs designed to meet their individual needs.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab