Penn Spine and Rehab Logo

Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

Need Help Finding the Right Treatment?

Browse our directory or call to discuss treatment options.

Call 1(223) 235-7839
12,000+ Centers
SAMHSA Data
Filters:

Showing 20 of 8160 depression rehab centers

Access Blue Island Family Health Ctr
+9 photos

Access Blue Island Family Health Ctr

Blue Island, IL

Access Blue Island Family Health Center, located in Blue Island, IL, provides outpatient treatment for adults and young adults who are dealing with both substance use and significant mental health issues. The center has developed specialized programs specifically for adult men, adult women, and individuals living with HIV or AIDS, ensuring that care is customized to meet a variety of needs. Treatment options at this facility include brief interventions, counseling for substance use disorders, and outpatient therapies such as methadone, buprenorphine, or naltrexone. With a strong emphasis on high-quality care and personalized support, this center serves both male and female clients who are in search of effective rehabilitation programs within a welcoming atmosphere.

Daymark Recovery Services
+9 photos

Daymark Recovery Services

Raeford, NC

Located in Raeford, NC, Daymark Recovery Services provides a range of outpatient treatment options for substance use, catering to both adults and children who also face mental health challenges. The facility has tailored programs designed specifically for adult men, adult women, and individuals who have experienced sexual abuse. Their treatment methods encompass anger management, brief intervention, and cognitive behavioral therapy. Daymark offers a variety of services, including outpatient care, as well as methadone/buprenorphine and naltrexone options, to meet the unique needs of every client. Whether serving men or women, Daymark Recovery Services is dedicated to delivering high-quality care that empowers individuals on their recovery journey.

Colorado Medication Assisted Recovery
+9 photos

Colorado Medication Assisted Recovery

Denver, CO

Located in Denver, CO, Colorado Medication Assisted Recovery is a premier facility specializing in intensive outpatient care for individuals grappling with substance use disorders alongside co-occurring mental health issues. This center offers customized programs specifically designed for adult women and clients with dual diagnoses, ensuring that each person receives the comprehensive support they need. The treatment approach incorporates evidence-based techniques, including cognitive behavioral therapy and contingency management, emphasizing not just long-term recovery but also holistic well-being. Colorado Medication Assisted Recovery provides effective outpatient treatments with options like methadone/buprenorphine or naltrexone. This facility is dedicated to delivering high-quality care tailored to adults and young adults of all genders who are working to conquer addiction and enhance their mental health.

Taproot Therapy Collective
+9 photos

Taproot Therapy Collective

Birmingham, AL

Located in Birmingham, AL, Taproot Therapy Collective specializes in outpatient treatment for substance use and offers targeted support for adults grappling with co-occurring disorders related to both substance use and serious mental health challenges, as well as emotional issues in children. The facility provides a variety of regular outpatient services that incorporate evidence-based methods, including anger management, brief interventions, and cognitive behavioral therapy. The center uniquely addresses the needs of active duty military members, adolescents, and adult men through tailored programs. At Taproot Therapy Collective, every client—whether an adult or senior of any gender—receives personalized care designed to meet their specific needs, establishing it as an essential resource for those in search of effective and comprehensive rehabilitation services.

New Beginnings Recovery Center LLC
+9 photos

New Beginnings Recovery Center LLC

Seymour, IN

New Beginnings Recovery Center LLC, situated in Seymour, IN, offers a variety of rehabilitation services specifically designed to assist both adults and children who are facing challenges related to substance use and co-occurring mental health issues. The center features intensive outpatient treatment, outpatient day treatment, and partial hospitalization programs. Their approach includes methods such as 12-step facilitation, anger management, and brief interventions. Additionally, they provide specialized programs aimed at adolescents, adult men, and adult women, ensuring that they meet the needs of different age groups and genders. With a strong commitment to delivering high-quality care and support, New Beginnings Recovery Center LLC helps individuals take significant steps towards achieving lasting recovery.

Aurora Medical Center Sheboygan County
+9 photos

Aurora Medical Center Sheboygan County

Sheboygan, WI

Aurora Medical Center Sheboygan County, situated in Sheboygan, WI, provides a wide range of addiction treatment services for both adults and children. The center features inpatient detoxification within a hospital setting, focusing on recovery from substance use disorders, including cases involving co-occurring mental health challenges. With methods such as brief intervention and motivational interviewing, the facility emphasizes personalized care designed to encourage sustained recovery. It offers specialized programs tailored for adults and adolescents, as well as distinct treatment paths for males and females, ensuring that every patient receives the support they need. For individuals in search of high-quality, customized addiction treatment, Aurora Medical Center Sheboygan County stands out as a reliable option.

Camillus House
+9 photos

Camillus House

Miami, FL

Situated in Miami, FL, Camillus House provides extensive addiction treatment aimed at both adults and young adults facing challenges with substance use and concurrent mental health disorders. The center offers a range of options, including long-term residential, outpatient, and regular outpatient programs, ensuring specialized care through approaches like 12-step facilitation, anger management, and cognitive behavioral therapy. They also feature distinctive programs designed specifically for adult men, adult women, and individuals who have experienced intimate partner violence. Committed to quality care, this facility focuses on delivering customized services in a nurturing and professional setting for all its clients.

Pyramid Healthcare Inc
+9 photos

Pyramid Healthcare Inc

Duncansville, PA

Located in Duncansville, PA, Pyramid Healthcare Inc provides a wide range of addiction treatment services geared toward adults and young adults struggling with substance use disorders and co-occurring mental health issues. Emphasizing long-term residential care, the facility features specialized programs designed specifically for active duty military personnel and caters to both adult men and women. The treatment approaches here are personalized and include options such as 12-step facilitation, anger management, and cognitive behavioral therapy. With a commitment to maintaining high standards of care for all clients, Pyramid Healthcare Inc stands out as an excellent choice for those looking for effective and customized rehabilitation programs.

WhiteSands Alcohol and Drug Rehab
+9 photos

WhiteSands Alcohol and Drug Rehab

Melbourne, FL

WhiteSands Alcohol and Drug Rehab, located in Melbourne, FL, provides thorough substance use treatment for both adults and young adults who are also dealing with co-occurring mental health conditions. The center offers a range of services, including intensive outpatient and outpatient programs, as well as methadone, buprenorphine, or naltrexone treatments. With an emphasis on 12-step facilitation, anger management, and brief intervention techniques, the facility serves adult men and women, along with active duty military personnel. Recognizing the unique needs of individuals, WhiteSands offers specialized programs tailored specifically for male and female clients. Committed to high-quality, evidence-based approaches, WhiteSands Alcohol and Drug Rehab aims to support those on their journey to recovery from addiction and dual diagnoses.

Nooksack Tribes Genesis II
+9 photos

Nooksack Tribes Genesis II

Everson, WA

Nooksack Tribes Genesis II, situated in Everson, WA, provides a wide range of substance use treatment programs tailored for both adults and adolescents. The facility emphasizes intensive outpatient treatment, alongside outpatient and regular outpatient services, ensuring a comprehensive approach to care. Here, specialized programs cater to adult men, adult women, and adolescents, utilizing evidence-based strategies like 12-step facilitation, brief intervention, and the Matrix Model. Each client receives customized treatment plans designed to address their unique needs. Furthermore, Nooksack Tribes Genesis II offers gender-specific programs, guaranteeing quality support and care for individuals on their path to recovery from substance use disorders.

HealthRIGHT 360
+9 photos

HealthRIGHT 360

San Francisco, CA

Located in San Francisco, CA, HealthRIGHT 360 provides outpatient substance use treatment for both adult men and women, including individuals who have faced trauma. At this center, clients receive ongoing outpatient care grounded in evidence-based methods such as 12-step facilitation, anger management, and cognitive behavioral therapy. With specialized programs designed for adult men, adult women, and those who have experienced trauma, the facility is committed to meeting the diverse needs of its clients. HealthRIGHT 360 serves adults and young adults of all genders, ensuring that everyone receives comprehensive care tailored to their specific circumstances. Discover quality addiction treatment in a nurturing environment at this esteemed rehabilitation center.

Crossroads Treatment Centers
+9 photos

Crossroads Treatment Centers

Louisville, KY

Located in Louisville, KY, Crossroads Treatment Centers offers outpatient services specifically designed for those struggling with substance use. Their expertise lies in methadone, buprenorphine, and naltrexone therapy. The facility emphasizes relapse prevention, provides counseling for substance use disorders, and offers telemedicine and telehealth options to make accessing care more convenient. With a particular focus on supporting pregnant and postpartum women, Crossroads serves adults and young adults of all genders. Their comprehensive approach, alongside personalized programs, ensures that each individual receives the tailored support they need on their journey to recovery. Crossroads Treatment Centers is committed to delivering high-quality, evidence-based care, empowering clients to achieve lasting recovery from addiction.

Scranton Counseling Center
+9 photos

Scranton Counseling Center

Scranton, PA

Situated in Scranton, PA, Scranton Counseling Center provides an extensive array of rehabilitation services. The facility focuses on treating substance use issues, offering transitional housing, and addressing the needs of individuals with co-occurring substance use and serious mental health disorders in adults, as well as emotional disturbances in children. With a variety of treatment options that include intensive outpatient, outpatient, and regular outpatient services, the center emphasizes personalized care through methods like anger management, brief intervention, and cognitive behavioral therapy. Additionally, there are specialized programs designed for active duty military personnel, adolescents, and adult men. Committed to serving both adults and children/adolescents, the center ensures that services are accessible to all clients, regardless of gender. This dedication to high-quality care is evident in their tailored approaches to meet each individual’s unique needs.

VA Roseburg Healthcare System
+9 photos

VA Roseburg Healthcare System

Roseburg, OR

The VA Roseburg Healthcare System, situated in Roseburg, OR, provides a range of comprehensive substance use treatment programs. Here, you can access outpatient services such as methadone/buprenorphine or naltrexone treatment, regular outpatient therapy, and brief interventions. The center focuses on cognitive behavioral therapy and motivational interviewing, ensuring a tailored approach to each individual's needs. There are specialized programs designed specifically for those who have experienced trauma and for veterans as well. This facility welcomes adults and young adults of all genders, offering high-quality care and specialized services. If you or someone you care about is in search of effective addiction treatment, consider the VA Roseburg Healthcare System for personalized, evidence-based support.

SalusCare
+9 photos

SalusCare

Fort Myers, FL

Located in Fort Myers, FL, SalusCare offers a variety of outpatient treatment programs that address substance use and co-occurring mental health issues for both adults and children. The center features specialized services, including outpatient methadone/buprenorphine treatments and 12-step facilitation. SalusCare employs individualized strategies such as anger management and brief intervention to support adolescents, adult women, and those dealing with dual diagnoses. Committed to providing high-quality care, this facility serves adults and seniors of all genders who are on their journey to recovery from addiction and mental health difficulties.

Orlando VAMC
+9 photos

Orlando VAMC

Melbourne, FL

Situated in Melbourne, FL, the Orlando VAMC is dedicated to providing thorough substance use treatment for adults grappling with co-occurring mental health challenges. The facility offers both intensive outpatient and outpatient programs, which include options for methadone and buprenorphine treatment. By utilizing techniques such as 12-step facilitation, anger management, and brief interventions, the center serves adult men and women, as well as those who have faced intimate partner violence. With a focus on adults and seniors of all genders, the Orlando VAMC strives to deliver quality care that is tailored to meet each individual's unique needs, fostering a supportive atmosphere for recovery.

Little Creek Recovery
+9 photos

Little Creek Recovery

Lake Ariel, PA

Nestled in Lake Ariel, PA, Little Creek Recovery provides high-quality substance use treatment specifically designed for adult men in a peaceful residential environment. The facility offers a variety of programs, including long-term, short-term, and 24-hour residential treatment options. Utilizing proven methods such as 12-step facilitation, cognitive behavioral therapy, and the Matrix Model, Little Creek Recovery is committed to delivering specialized care. The center caters to adults, seniors, and young adults, but it truly excels with its dedicated programs for adult men. If you're looking for effective addiction treatment within a supportive setting, Little Creek Recovery is a reputable option, well-regarded for its comprehensive services and dedication to helping individuals achieve sustainable recovery.

Evergreen Treatment Center
+9 photos

Evergreen Treatment Center

Paramus, NJ

Evergreen Treatment Center, situated in Paramus, NJ, provides a wide range of addiction treatment services designed for both adults and adolescents. This facility features hospital inpatient detoxification and treatment options that incorporate various methods, including 12-step facilitation, brief intervention, and cognitive behavioral therapy. A key focus at Evergreen is the treatment of clients who are dealing with both mental health and substance use disorders. With tailored programs available for male and female clients, as well as specialized care for adolescents, Evergreen Treatment Center is committed to delivering personalized, high-quality care that supports each individual's recovery journey. If you or someone you care about is looking for effective and compassionate help with substance use issues, you can count on Evergreen Treatment Center to offer the support and resources needed for lasting recovery.

Woodhull Medical Center
+9 photos

Woodhull Medical Center

Brooklyn, NY

Nestled in Brooklyn, NY, Woodhull Medical Center specializes in rehabilitation services for both adults and young adults who are facing substance use disorders alongside mental health challenges. The facility offers a variety of treatment options, including outpatient detox and intensive outpatient programs. With a commitment to personalized care, Woodhull employs evidence-based methods such as 12-step facilitation, anger management, and brief interventions to aid in the recovery process. Catering to both men and women, the center ensures that each treatment plan is customized to meet the unique needs of every individual. If you or someone you care about is in search of thorough and empathetic addiction treatment, Woodhull Medical Center stands ready to provide the quality care needed to support your recovery journey.

Recovery Village Ridgefield
+9 photos

Recovery Village Ridgefield

Ridgefield, WA

Recovery Village Ridgefield, situated in Ridgefield, WA, provides a wide range of addiction treatment services designed for both adults and young adults. The facility offers hospital inpatient detoxification and comprehensive treatment for those struggling with substance use disorders, alongside addressing co-occurring mental health conditions. It features tailored programs specifically for active duty military members, as well as adult men and women, ensuring that various needs are met effectively. With a focus on individualized care, Recovery Village Ridgefield employs a variety of therapeutic approaches, including 12-step facilitation, anger management strategies, and brief interventions. The center is committed to serving adults, seniors, and young adults of all genders, consistently emphasizing the importance of high-quality treatment to foster long-term recovery.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • •Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • •Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • •Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • •Genetic predisposition — shared hereditary risk factors for both conditions
  • •Childhood trauma and adverse experiences
  • •Chronic stress, grief, loss, or major life changes
  • •Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab