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Medication-Assisted Treatment (MAT) Treatment Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Medication-Assisted Treatment (MAT) is considered the gold standard for opioid use disorder and is also effective for alcohol addiction. MAT combines FDA-approved medications like buprenorphine, methadone, or naltrexone with counseling and behavioral therapies, significantly improving treatment outcomes and reducing overdose risk.

Found 5,839 treatment centers offering medication-assisted treatment (mat) across the United States.

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Showing 20 of 5839 medication-assisted treatment (mat) treatment centers

Daymark Recovery Services - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Active duty military+1 more
Daymark Recovery Services - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adolescents+1 more
DeCoach Rehabilitation Centre - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
Active duty military+1 more
Delaware Valley Medical - Facility Image
+9 photos

Delaware Valley Medical

Merchantville, NJ

Insurance Accepted$$
Substance use treatment
Pregnant/postpartum women
Desoto County Treatment Center - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Detroit Rescue Mission Ministries - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adult women+1 more
Dimock Center - Facility Image
+9 photos

Dimock Center

Roxbury, MA

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adult men+1 more
Dover Comprehensive Treatment Center - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Eagle Healthworks - Facility Image
+9 photos

Eagle Healthworks

Byesville, OH

Insurance Accepted$$
Substance use treatment
Eastern Oklahoma VA Healthcare System - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Clients who have experienced intimate partner violence, domestic violence+1 more
Ebb Tide Treatment LLC - Facility Image
+9 photos

Ebb Tide Treatment LLC

West Palm Beach, FL

Insurance Accepted$$
Substance use treatmentTransitional housing, halfway house, or sober home+1 more
Active duty military+1 more
Eleanor Health - Facility Image
+9 photos

Eleanor Health

Verona, NJ

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Eleanor Health - Facility Image
+9 photos

Eleanor Health

Edison, NJ

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Elkton Comprehensive Treatment Center - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Active duty military+1 more
Elmhurst Hospital Center - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
Adult men+1 more
Evolve Life Centers - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adult men+1 more
Extension Inc - Facility Image
+9 photos

Extension Inc

Marietta, GA

$$
Substance use treatment
Active duty military+1 more
Fellowship House Inc - Facility Image
+9 photos

Fellowship House Inc

Birmingham, AL

$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adult men+1 more
Fort Wayne Recovery - Facility Image
+9 photos

Fort Wayne Recovery

Fort Wayne, IN

Insurance Accepted$$
Substance use treatmentTransitional housing, halfway house, or sober home+1 more
Adult men+1 more
Freedom Recovery - Facility Image
+9 photos

Freedom Recovery

Columbus, OH

Insurance Accepted$$
Substance use treatment

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment represents a significant advancement in addiction medicine, dramatically improving outcomes for opioid and alcohol use disorders. At Penn Spine and Rehab, we connect you with MAT providers who combine medication with comprehensive behavioral treatment.

FDA-Approved Medications

For opioid addiction:

  • Buprenorphine (Suboxone, Subutex): Reduces cravings and withdrawal symptoms
  • Methadone: Prevents withdrawal and reduces cravings in supervised settings
  • Naltrexone (Vivitrol): Blocks opioid effects and reduces cravings

For alcohol addiction:

  • Naltrexone: Reduces cravings and the rewarding effects of alcohol
  • Acamprosate (Campral): Helps maintain abstinence after detox
  • Disulfiram (Antabuse): Creates unpleasant effects if alcohol is consumed

MAT Is Not "Replacing One Drug with Another"

A common misconception is that MAT simply substitutes one addiction for another. In reality, MAT medications stabilize brain chemistry, allowing individuals to engage in therapy, maintain employment, and rebuild their lives while reducing overdose risk and relapse rates.

Finding MAT Providers

MAT is available in various settings including outpatient clinics, intensive outpatient programs, and residential treatment centers. Look for programs that combine medication with behavioral therapy for the best outcomes.

Medication-Assisted Treatment (MAT) Key Statistics

50%
reduction in overdose death risk with buprenorphine treatment
Source: The Lancet Psychiatry
75%
retention rate in MAT programs vs. 25% without medication
Source: SAMHSA National Survey
60%
decrease in criminal activity among MAT participants
Source: National Institute on Drug Abuse
3x
more likely to remain in treatment with MAT vs. without
Source: World Health Organization

Conditions Treated with Medication-Assisted Treatment (MAT)

MAT is the gold standard treatment for opioid use disorder

Naltrexone, acamprosate, and disulfiram treat alcohol dependence

MAT stabilizes addiction so co-occurring conditions can be treated

MAT treats dependence on prescription opioids like oxycodone and hydrocodone

What to Expect: Medication-Assisted Treatment (MAT) Treatment Process

1

Medical Assessment

Day 1

Comprehensive evaluation including substance use history, medical exam, and lab tests

2

Induction

Days 1-7

Medication is carefully started at low doses under medical supervision and gradually increased

3

Stabilization

Weeks 2-8

Dose is adjusted until cravings and withdrawal are managed; counseling begins

4

Maintenance

Months to years

Ongoing medication with regular counseling, support groups, and medical monitoring

Frequently Asked Questions About Medication-Assisted Treatment (MAT)

Medical Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any treatment program. If you are experiencing a medical emergency, call 911 immediately.