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Medication-Assisted Treatment (MAT) Treatment Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Medication-Assisted Treatment (MAT) is considered the gold standard for opioid use disorder and is also effective for alcohol addiction. MAT combines FDA-approved medications like buprenorphine, methadone, or naltrexone with counseling and behavioral therapies, significantly improving treatment outcomes and reducing overdose risk.

Found 5,839 treatment centers offering medication-assisted treatment (mat) across the United States.

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Showing 20 of 5839 medication-assisted treatment (mat) treatment centers

Anne Arundel County Department of Hlth - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Clients with HIV or AIDS+1 more
Another Chance Clinical Services LLC - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Active duty military+1 more
Another Way Inc - Facility Image
+9 photos

Another Way Inc

Takoma Park, MD

Insurance Accepted$$
DetoxificationSubstance use treatment
Adult men+1 more
Applegate Recovery - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Active duty military+1 more
Applegate Recovery - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
AppleGate Recovery - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Active duty military+1 more
AppleGate Recovery - Facility Image
+9 photos

AppleGate Recovery

Fort Wayne, IN

Insurance Accepted$$
DetoxificationSubstance use treatment
Active duty military+1 more
AppleGate Recovery of El Dorado - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Active duty military+1 more
Appleton Comprehensive Treatment Ctr - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Active duty military+1 more
APS Clinics of Puerto Rico - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Archstone Behavioral Health - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
Adult men+1 more
Area Substance Abuse Council - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTransitional housing, halfway house, or sober home+1 more
Active duty military+1 more
Arisa Health - Facility Image
+9 photos

Arisa Health

Jonesboro, AR

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Criminal justice (other than DUI/DWI)/Forensic clients
Arisa Health - Facility Image
+9 photos

Arisa Health

Springdale, AR

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Arise Recovery Centers - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Adult men+1 more
Arista Recovery - Facility Image
+9 photos
Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
Arizona Recovery Center - Facility Image
+9 photos

Arizona Recovery Center

Lake Havasu City, AZ

Insurance Accepted$$
DetoxificationSubstance use treatment
Active duty military+1 more
Arizona Womens Recovery Center - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTransitional housing, halfway house, or sober home+1 more
Adult women+1 more
Arkview Recovery Center - Facility Image
+9 photos

Arkview Recovery Center

Mechanicsburg, PA

Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
Adult men+1 more
ARS of Ephrata - Facility Image
+9 photos

ARS of Ephrata

Ephrata, PA

Insurance Accepted$$
Substance use treatment
Clients who have experienced trauma+1 more

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment represents a significant advancement in addiction medicine, dramatically improving outcomes for opioid and alcohol use disorders. At Penn Spine and Rehab, we connect you with MAT providers who combine medication with comprehensive behavioral treatment.

FDA-Approved Medications

For opioid addiction:

  • Buprenorphine (Suboxone, Subutex): Reduces cravings and withdrawal symptoms
  • Methadone: Prevents withdrawal and reduces cravings in supervised settings
  • Naltrexone (Vivitrol): Blocks opioid effects and reduces cravings

For alcohol addiction:

  • Naltrexone: Reduces cravings and the rewarding effects of alcohol
  • Acamprosate (Campral): Helps maintain abstinence after detox
  • Disulfiram (Antabuse): Creates unpleasant effects if alcohol is consumed

MAT Is Not "Replacing One Drug with Another"

A common misconception is that MAT simply substitutes one addiction for another. In reality, MAT medications stabilize brain chemistry, allowing individuals to engage in therapy, maintain employment, and rebuild their lives while reducing overdose risk and relapse rates.

Finding MAT Providers

MAT is available in various settings including outpatient clinics, intensive outpatient programs, and residential treatment centers. Look for programs that combine medication with behavioral therapy for the best outcomes.

Medication-Assisted Treatment (MAT) Key Statistics

50%
reduction in overdose death risk with buprenorphine treatment
Source: The Lancet Psychiatry
75%
retention rate in MAT programs vs. 25% without medication
Source: SAMHSA National Survey
60%
decrease in criminal activity among MAT participants
Source: National Institute on Drug Abuse
3x
more likely to remain in treatment with MAT vs. without
Source: World Health Organization

Conditions Treated with Medication-Assisted Treatment (MAT)

MAT is the gold standard treatment for opioid use disorder

Naltrexone, acamprosate, and disulfiram treat alcohol dependence

MAT stabilizes addiction so co-occurring conditions can be treated

MAT treats dependence on prescription opioids like oxycodone and hydrocodone

What to Expect: Medication-Assisted Treatment (MAT) Treatment Process

1

Medical Assessment

Day 1

Comprehensive evaluation including substance use history, medical exam, and lab tests

2

Induction

Days 1-7

Medication is carefully started at low doses under medical supervision and gradually increased

3

Stabilization

Weeks 2-8

Dose is adjusted until cravings and withdrawal are managed; counseling begins

4

Maintenance

Months to years

Ongoing medication with regular counseling, support groups, and medical monitoring

Frequently Asked Questions About Medication-Assisted Treatment (MAT)

Medical Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any treatment program. If you are experiencing a medical emergency, call 911 immediately.

Medication-Assisted Treatment (MAT) | Penn Spine and Rehab