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Medication-Assisted Treatment (MAT) Treatment Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Medication-Assisted Treatment (MAT) is considered the gold standard for opioid use disorder and is also effective for alcohol addiction. MAT combines FDA-approved medications like buprenorphine, methadone, or naltrexone with counseling and behavioral therapies, significantly improving treatment outcomes and reducing overdose risk.

Found 5,839 treatment centers offering medication-assisted treatment (mat) across the United States.

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Showing 20 of 5839 medication-assisted treatment (mat) treatment centers

Woonsocket Comprehensive Treatment Ctr - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatment
Adult men+1 more
Workit Health MI - Facility Image
+9 photos

Workit Health MI

Ann Arbor, MI

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Clients who have experienced trauma+1 more
Yana House - Facility Image
+9 photos

Yana House

Chicago, IL

$$
Substance use treatmentTransitional housing, halfway house, or sober home
Adult men+1 more
YMCA of Honolulu - Facility Image
+9 photos

YMCA of Honolulu

Waipahu, HI

$$
Substance use treatment
Adolescents
YMCA of Honolulu - Facility Image
+9 photos

YMCA of Honolulu

Wahiawa, HI

$$
Substance use treatment
Adolescents
Zinnia Exeter - Facility Image
+9 photos

Zinnia Exeter

Exeter, RI

Insurance Accepted$$
DetoxificationSubstance use treatment
Adult men+1 more
Zucker Hillside Hospital Northwell - Facility Image
+9 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adult men+1 more
Addiction Research and Treatment Inc - Facility Image
+8 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Pregnant/postpartum women
Aegis Treatment Centers LLC - Facility Image
+8 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Criminal justice (other than DUI/DWI)/Forensic clients+1 more
Aegis Treatment Centers LLC - Facility Image
+8 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Pregnant/postpartum women
Applegate Recovery - Facility Image
+8 photos

Applegate Recovery

Bowling Green, KY

Insurance Accepted$$
Substance use treatment
AppleGate Recovery - Facility Image
+8 photos

AppleGate Recovery

Charleston, WV

Insurance Accepted$$
DetoxificationSubstance use treatment+1 more
BCD Hoover Treatment Center - Facility Image
+8 photos
Insurance Accepted$$
Substance use treatmentTransitional housing, halfway house, or sober home
Adult men+1 more
Behavioral Health Services - Facility Image
+8 photos
Insurance Accepted$$
Substance use treatment
Adult women+1 more
Best Option LLC - Facility Image
+8 photos

Best Option LLC

San Antonio, TX

$$
Substance use treatment
Adult men+1 more
BHG Nashville Treatment Center - Facility Image
+8 photos
Insurance Accepted$$
DetoxificationSubstance use treatment
Adult men+1 more
Boston Public Health Commission - Facility Image
+8 photos
Insurance Accepted$$
Substance use treatment
Adult women+1 more
Brightside Recovery Ltd - Facility Image
+8 photos
$$
Substance use treatment
Adult men+1 more
CARE Center Inc - Facility Image
+8 photos

CARE Center Inc

Washington, PA

Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adolescents+1 more
Caring Center of Wichita - Facility Image
+8 photos
Insurance Accepted$$
Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Adolescents+1 more

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment represents a significant advancement in addiction medicine, dramatically improving outcomes for opioid and alcohol use disorders. At Penn Spine and Rehab, we connect you with MAT providers who combine medication with comprehensive behavioral treatment.

FDA-Approved Medications

For opioid addiction:

  • Buprenorphine (Suboxone, Subutex): Reduces cravings and withdrawal symptoms
  • Methadone: Prevents withdrawal and reduces cravings in supervised settings
  • Naltrexone (Vivitrol): Blocks opioid effects and reduces cravings

For alcohol addiction:

  • Naltrexone: Reduces cravings and the rewarding effects of alcohol
  • Acamprosate (Campral): Helps maintain abstinence after detox
  • Disulfiram (Antabuse): Creates unpleasant effects if alcohol is consumed

MAT Is Not "Replacing One Drug with Another"

A common misconception is that MAT simply substitutes one addiction for another. In reality, MAT medications stabilize brain chemistry, allowing individuals to engage in therapy, maintain employment, and rebuild their lives while reducing overdose risk and relapse rates.

Finding MAT Providers

MAT is available in various settings including outpatient clinics, intensive outpatient programs, and residential treatment centers. Look for programs that combine medication with behavioral therapy for the best outcomes.

Medication-Assisted Treatment (MAT) Key Statistics

50%
reduction in overdose death risk with buprenorphine treatment
Source: The Lancet Psychiatry
75%
retention rate in MAT programs vs. 25% without medication
Source: SAMHSA National Survey
60%
decrease in criminal activity among MAT participants
Source: National Institute on Drug Abuse
3x
more likely to remain in treatment with MAT vs. without
Source: World Health Organization

Conditions Treated with Medication-Assisted Treatment (MAT)

MAT is the gold standard treatment for opioid use disorder

Naltrexone, acamprosate, and disulfiram treat alcohol dependence

MAT stabilizes addiction so co-occurring conditions can be treated

MAT treats dependence on prescription opioids like oxycodone and hydrocodone

What to Expect: Medication-Assisted Treatment (MAT) Treatment Process

1

Medical Assessment

Day 1

Comprehensive evaluation including substance use history, medical exam, and lab tests

2

Induction

Days 1-7

Medication is carefully started at low doses under medical supervision and gradually increased

3

Stabilization

Weeks 2-8

Dose is adjusted until cravings and withdrawal are managed; counseling begins

4

Maintenance

Months to years

Ongoing medication with regular counseling, support groups, and medical monitoring

Frequently Asked Questions About Medication-Assisted Treatment (MAT)

Medical Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any treatment program. If you are experiencing a medical emergency, call 911 immediately.

Medication-Assisted Treatment (MAT) | Penn Spine and Rehab