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Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

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Showing 20 of 8160 depression rehab centers

Rosecrance Jackson Centers

Rosecrance Jackson Centers

Sheldon, IA

Rosecrance Jackson Centers, located in Sheldon, IA, provide outpatient substance use treatment for both adults and children/adolescents. The center emphasizes personalized care, offering regular outpatient services that incorporate 12-step facilitation, brief intervention, and cognitive behavioral therapy. Catering to both male and female clients, this facility fosters a welcoming environment aimed at supporting recovery. A standout aspect of their program is its customized approach, designed to address the unique needs of each person. If you or someone you know is looking for detailed addiction treatment infused with a personal touch, Rosecrance Jackson Centers is a dependable option for quality care and support.

Arrowleaf

Arrowleaf

Elizabethtown, IL

Located in Elizabethtown, IL, Arrowleaf provides outpatient substance use treatment for adults facing serious mental health challenges alongside their addiction. The center emphasizes regular outpatient services and specializes in brief intervention, cognitive behavioral therapy, and motivational interviewing. With a commitment to personalization, Arrowleaf creates tailored treatment plans for adult and senior clients of all genders. Their thorough approach guarantees that each individual receives care specifically designed to meet their needs. If you’re looking for compassionate and quality addiction treatment, Arrowleaf is here to help you on your path to recovery.

Aspire Health Partners

Aspire Health Partners

Orlando, FL

Aspire Health Partners, located in Orlando, FL, provides an extensive range of addiction treatment programs tailored for both adults and young adults struggling with substance use disorders and concurrent mental health issues. Their services encompass detoxification, intensive outpatient treatment, and outpatient detoxification. The facility emphasizes 12-step facilitation, anger management, and brief interventions. Aspire Health Partners is particularly attuned to the needs of individuals who have faced trauma, as well as pregnant and postpartum women. With customized programs designed for men and women alike, the center fosters a supportive and welcoming atmosphere for those on their journey to recovery. Their commitment to high-quality care and evidence-based methods makes this facility a leading option for anyone seeking to overcome the challenges of addiction.

Alta Counseling and Testing LLC

Alta Counseling and Testing LLC

Tacoma, WA

Situated in Tacoma, WA, Alta Counseling and Testing LLC provides tailored substance use treatment programs designed for both adults and young adults. The center specializes in intensive outpatient treatment, regular outpatient care, and relapse prevention, delivering thorough assistance through brief interventions and counseling for substance use disorders. With customized programs specifically for active duty military personnel as well as adult men and women, Alta ensures that each individual receives the care they need. The facility serves both male and female clients and places a high priority on delivering quality care to help individuals effectively navigate the challenges of addiction. If you’re looking for personalized, evidence-based treatment, you can count on Alta Counseling and Testing LLC to support you on your recovery journey.

Partners Behavioral Healthcare

Partners Behavioral Healthcare

Minneapolis, MN

Located in Minneapolis, MN, Partners Behavioral Healthcare is dedicated to treating substance use disorders among adult, senior, and young adult males. The center provides a range of services, including intensive outpatient, outpatient, and day treatment programs. With a strong emphasis on evidence-based methods such as cognitive behavioral therapy and anger management, they ensure that clients receive effective care. Moreover, they offer specialized programs designed for individuals facing co-occurring mental health and substance use issues, including those involved in the forensic system. At Partners Behavioral Healthcare, the focus is on delivering personalized care that supports each client's journey toward recovery and lasting wellness.

La Jolla Healing Center

La Jolla Healing Center

La Jolla, CA

Nestled in La Jolla, CA, the La Jolla Healing Center is dedicated to providing thorough rehabilitation services for both adults and young adults who are struggling with substance use disorders, along with co-occurring mental health issues. The center offers a range of treatment options, including intensive outpatient treatment, outpatient day treatment, and partial hospitalization programs. With an emphasis on 12-step facilitation, anger management, and brief interventions, the center tailors its approach to meet the specific needs of active duty military personnel, as well as adult men and women. Their specialized programs and gender-focused care allow for personalized treatment plans that support long-term recovery and holistic healing.

Counseling Associates Inc

Counseling Associates Inc

Clarksville, AR

Situated in Clarksville, AR, Counseling Associates Inc specializes in outpatient treatment for adults dealing with substance use and co-occurring mental health challenges, as well as emotional disturbances in children. They offer a range of treatment options, such as methadone, buprenorphine, or naltrexone, along with cognitive behavioral therapy, motivational interviewing, and strategies for relapse prevention. This facility places a strong emphasis on assisting criminal justice and forensic clients, serving adults and seniors of all genders. At Counseling Associates Inc, the commitment to delivering quality care and personalized programs is evident as they support individuals on their path to recovery.

Restoration Recovery Cleveland

Restoration Recovery Cleveland

Cleveland, TN

Located in Cleveland, TN, Restoration Recovery Cleveland provides outpatient treatment options for those dealing with substance use issues. Their offerings include outpatient programs for methadone/buprenorphine or naltrexone treatment as well as standard outpatient care. The center is dedicated to various therapeutic methods, including cognitive behavioral therapy, motivational interviewing, and strategies for relapse prevention. They feature specialized programs designed for adult men, adult women, and clients facing both mental health and substance use challenges. Catering to adults and young adults of all genders, this facility emphasizes personalized care and evidence-based methods to assist individuals in their recovery journey. With a commitment to high-quality services and tailored treatment plans, Restoration Recovery Cleveland is a reliable option for anyone seeking effective support in overcoming addiction.

Helm DUI Services

Helm DUI Services

Vandalia, IL

Helm DUI Services, situated in Vandalia, IL, provides a wide range of substance use treatment options for both adults and young adults. The facility offers intensive outpatient treatment as well as outpatient and regular outpatient programs. With an emphasis on 12-step facilitation, anger management, and brief intervention strategies, Helm DUI Services is dedicated to meeting the needs of both male and female clients. Notably, the center specializes in helping clients involved in the criminal justice system, offering customized programs designed to fit their unique circumstances. Patients can look forward to receiving high-quality care and personalized treatment plans that support them on their path to recovery.

Kingsboro ATC

Kingsboro ATC

Brooklyn, NY

Situated in Brooklyn, NY, Kingsboro ATC delivers exceptional substance use treatment within a residential environment. The facility emphasizes a blend of 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, offering personalized care for adult men and women, along with young adults who have faced trauma. With specialized programs designed to meet the distinct needs of each client, Kingsboro ATC ensures thorough support throughout the recovery process. The center takes pride in providing quality care that is specifically tailored to each individual's requirements, making it a reliable option for those in search of effective and compassionate addiction treatment.

VOA Behavioral Health Services

VOA Behavioral Health Services

Quincy, MA

Situated in Quincy, MA, VOA Behavioral Health Services delivers a wide variety of outpatient treatment options tailored for both substance use and co-occurring disorders, catering to both adults and children. This facility offers specialized services such as anger management, cognitive behavioral therapy, and brief interventions. With an emphasis on personalized care, the center provides dedicated programs for adolescents, adult men, and adult women. VOA Behavioral Health Services is dedicated to delivering quality treatment grounded in evidence-based methodologies, serving adults and seniors of all genders. Whether someone is looking for regular outpatient care or specific therapies like methadone, buprenorphine, or naltrexone, they will find compassionate support at this center.

MAAC Project

MAAC Project

Chula Vista, CA

Situated in Chula Vista, CA, the MAAC Project offers targeted substance use treatment specifically for adult men. This facility features various programs, including long-term, short-term, and around-the-clock residential options. With an emphasis on anger management, brief interventions, and cognitive behavioral therapy, the MAAC Project customizes its methods to address each individual's needs. They also provide unique programs designed for adult men who have faced issues such as intimate partner violence, domestic violence, or sexual abuse. Catering to adults, seniors, and young adults, the center is dedicated to delivering quality care with a specialized focus on male clients. For anyone in search of thorough and effective rehabilitation services, the MAAC Project is a reliable choice.

Human Resources Development Inst

Human Resources Development Inst

Chicago, IL

Situated in Chicago, IL, the Human Resources Development Institute specializes in providing rehabilitation services for adults and young adults facing challenges related to substance use and co-occurring mental health disorders. This center offers a range of options, including intensive outpatient treatment and outpatient care, along with methadone, buprenorphine, or naltrexone treatment alternatives. By emphasizing evidence-based practices such as cognitive behavioral therapy and contingency management, the facility addresses the distinctive needs of various groups, including active duty military personnel, adult women, and survivors of intimate partner violence. With customized programs available for both male and female clients, the center is dedicated to delivering high-quality care for those in pursuit of comprehensive and effective addiction treatment.

Samaritas

Samaritas

Charlotte, MI

Samaritas, situated in Charlotte, MI, stands out as a premier rehabilitation center dedicated to helping adults and seniors facing challenges related to substance use and co-occurring mental health concerns. The center offers a wide array of services, such as intensive outpatient treatment, outpatient detoxification, and ongoing outpatient care. These programs utilize evidence-based methods, including anger management, cognitive behavioral therapy, and brief interventions. One of the great things about Samaritas is its commitment to serving various groups, including adolescents, adult men, and women, with tailored programs designed to meet the unique needs of each demographic. With a strong emphasis on delivering high-quality care and personalized treatment plans, Samaritas is devoted to guiding clients through their recovery journeys.

Vincent P Dole Clinic

Vincent P Dole Clinic

Brooklyn, NY

The Vincent P Dole Clinic, situated in Brooklyn, NY, offers outpatient treatment for substance use with a focus on methadone, buprenorphine, and naltrexone programs. This facility is dedicated to providing quality care through various methods, including brief interventions, cognitive behavioral therapy, and motivational interviewing. One of the standout features of this clinic is its specialized programs designed for adult men, adult women, and members of the LGBTQ community. The clinic caters to both adults and young adults, welcoming clients of all genders. With an emphasis on customized treatment plans and a compassionate approach, the Vincent P Dole Clinic is devoted to helping individuals navigate their recovery journey.

Stepping Stone to Recovery

Stepping Stone to Recovery

Louisville, TN

Stepping Stone to Recovery, situated in Louisville, TN, is dedicated to providing a wide variety of addiction treatment services specifically tailored for adult women. At this facility, you can find intensive outpatient, long-term residential, and outpatient programs that incorporate methods like 12-step facilitation, anger management, and brief interventions. A key focus for Stepping Stone is on clients dealing with both substance use disorders and serious mental health issues. They also offer specialized programs for unique groups, including active duty military personnel, adult women, and individuals who have faced sexual abuse. Catering to adults, seniors, and young adults alike, this center aims to create a nurturing environment for women in search of effective care for their substance use and mental health challenges.

OREA LLC

OREA LLC

Silver Spring, MD

OREA LLC, situated in Silver Spring, MD, is a prominent outpatient rehabilitation center dedicated to substance use treatment. The center offers regular outpatient programs designed for adults and young adults, regardless of gender. By employing methods such as 12-step facilitation, anger management, and brief intervention, OREA LLC delivers thorough care to those facing addiction challenges. It particularly shines with its specialized programs catering to adult men, adult women, and individuals who have undergone intimate partner violence or domestic violence. With an emphasis on high-quality care and personalized treatment plans, this facility serves as a guiding light for those on their journey to recovery.

Life Changes Counseling

Life Changes Counseling

Reidsville, NC

Life Changes Counseling, located in Reidsville, NC, specializes in outpatient treatment for substance use disorders, emphasizing personalized counseling services. The facility offers consistent outpatient care, adapting its approach to meet the unique needs of adults, children, and adolescents alike. With dedicated programs designed for both men and women, Life Changes Counseling prioritizes individualized support to assist each client on their path to recovery. Their focus on high-quality care and customized treatment plans positions them as an essential resource for anyone in the Reidsville area looking for compassionate and effective addiction treatment services.

Compass Health

Compass Health

Warrensburg, MO

Compass Health, located in Warrensburg, MO, provides outpatient treatment for substance use as well as services for co-occurring mental health disorders for both adults and children. The facility employs brief intervention techniques, cognitive behavioral therapy, and motivational interviewing to create a customized care plan for clients facing dual diagnoses. Catering to adults and seniors of all genders, Compass Health is committed to addressing the distinct requirements of those with co-occurring conditions. With a strong emphasis on delivering quality, personalized treatment, this center strives to support clients in achieving long-lasting recovery and enhanced mental well-being.

Centerstone of Indiana Inc

Centerstone of Indiana Inc

Madison, IN

Located in Madison, IN, Centerstone of Indiana Inc provides extensive outpatient treatment for both adults and children dealing with substance use issues, especially those who also face co-occurring mental health concerns. Their range of programs features anger management, cognitive behavioral therapy, and dedicated services for individuals impacted by domestic violence. This facility offers outpatient treatments using methadone, buprenorphine, or naltrexone, alongside tailored outpatient care designed to meet the specific needs of men and women. Committed to delivering high-quality care and personalized treatment plans, Centerstone of Indiana Inc supports adults and seniors of all genders on their journey toward recovery from substance use disorders and mental health difficulties.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab