Penn Spine and Rehab Logo

Depression Rehab Centers

Written by Penn Spine and Rehab Editorial Team, CADC, LPC
Medically reviewed by Dr. James Mitchell, MD, FASAM
Last updated: March 27, 2026

Depression treatment within addiction recovery takes an integrated approach to address both conditions simultaneously. Evidence-based therapies like CBT and DBT, medication management when appropriate, and holistic wellness practices help individuals manage depressive symptoms while building a strong foundation for lasting sobriety.

Found 8,160 rehab centers specializing in depression across the United States.

Need Help Finding the Right Treatment?

Browse our directory or call to discuss treatment options.

Call 1(223) 235-7839
12,000+ Centers
SAMHSA Data
Filters:

Showing 20 of 8160 depression rehab centers

Clay Medical Center

Clay Medical Center

Flora, IL

Nestled in Flora, IL, Clay Medical Center specializes in outpatient treatment for substance use, welcoming both adults and children who are also facing significant mental health challenges. The center emphasizes a holistic path to recovery and offers regular outpatient services. There are special programs specifically designed for active duty military members, adolescents, and adult men. Catering to adults and seniors of all genders, this facility is dedicated to providing personalized and quality care, promoting lasting well-being. Clay Medical Center is recognized for its commitment to understanding the unique needs of each individual, reflected in their customized treatment plans and nurturing atmosphere.

Ascent Behavioral Health Services

Ascent Behavioral Health Services

Boise, ID

Ascent Behavioral Health Services, located in Boise, ID, provides a wide range of treatment options for substance use disorders alongside co-occurring mental health issues, benefiting both adults and children. The center offers various programs, including intensive outpatient, outpatient, and regular outpatient services, all designed to meet individual needs. By utilizing evidence-based practices such as 12-step facilitation, brief interventions, and cognitive behavioral therapy, Ascent ensures effective care for its clients. They also have specialized programs for adult men, adult women, and those dealing with co-occurring disorders. Committed to serving adults and young adults of all genders, Ascent Behavioral Health Services employs a multidisciplinary approach to foster long-lasting recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc

Waltham, MA

Spectrum Health Systems Inc, located in Waltham, MA, provides a wide range of substance use treatment options for adults facing serious mental health challenges as well as for children dealing with significant emotional issues. Their outpatient programs are designed to include specialized services for individuals who have experienced intimate partner violence. Utilizing methods such as 12-step facilitation and anger management, this facility tailors its approach to meet the unique needs of adult women and adolescents. With a strong emphasis on continuous care, Spectrum Health Systems Inc offers outpatient treatment options that include methadone, buprenorphine, or naltrexone. They serve both male and female clients, ensuring the delivery of quality care through brief interventions and consistent outpatient treatment.

MCCA

MCCA

Derby, CT

Situated in Derby, CT, MCCA provides a wide range of substance use treatment options. These include intensive outpatient programs, outpatient services, and medication-assisted treatments such as methadone, buprenorphine, or naltrexone. The center is particularly known for its focus on anger management, brief interventions, and cognitive behavioral therapy. MCCA offers specialized programs designed for adult men and women, as well as individuals dealing with both mental health and substance use challenges. Catering to adults and young adults regardless of gender, the center emphasizes personalized care that meets each client’s unique needs. With a strong reputation for delivering high-quality, evidence-based treatment, MCCA stands out as an excellent option for anyone looking for effective and tailored addiction rehabilitation services.

Anniston Fellowship House Inc

Anniston Fellowship House Inc

Anniston, AL

Anniston Fellowship House Inc, situated in Anniston, AL, offers excellent substance use treatment and transitional housing specifically for adult men. This facility is designed for long-term residential care, operating around the clock. Their approach combines 12-step facilitation, anger management, and brief intervention methods to support recovery. The program is inclusive, welcoming both seniors and younger adults who are seeking help. With a strong commitment to fostering a supportive atmosphere, this center focuses on effective rehabilitation through evidence-based practices. If you’re a man seeking comprehensive addiction treatment in a residential environment, Anniston Fellowship House Inc is here to assist you on your path to recovery.

Genesis Detox of Brooklyn LLC

Genesis Detox of Brooklyn LLC

Brooklyn, NY

Located in Brooklyn, NY, Genesis Detox of Brooklyn LLC specializes in detoxification and substance use treatment through residential programs. The facility offers round-the-clock care with an emphasis on 12-step facilitation, anger management, and brief intervention techniques. They provide customized programs for adult men and women, in addition to young adults. With a strong commitment to delivering quality care, this center serves both male and female clients and creates personalized treatment plans for adults pursuing thorough rehabilitation services. If you or someone you care about is seeking professional help for addiction, Genesis Detox of Brooklyn LLC is here to support your path to recovery.

Meridian Behavioral Health

Meridian Behavioral Health

Stillwater, MN

Situated in Stillwater, MN, Meridian Behavioral Health stands out as a leading rehabilitation center dedicated to providing specialized treatment for substance use disorders in both adults and young adults. The center emphasizes intensive outpatient, outpatient, and regular outpatient programs, delivering personalized care through techniques like motivational interviewing, relapse prevention, and counseling specific to substance use disorders. What sets Meridian Behavioral Health apart is its customized approach, serving both male and female clients who are looking for thorough addiction rehabilitation services. With a strong commitment to quality care, this center is recognized for its individualized programs that support individuals on their path to recovery.

CenterPointe

CenterPointe

Lincoln, NE

Located in Lincoln, NE, CenterPointe specializes in providing substance use treatment for adults dealing with co-occurring mental health issues, as well as for children facing serious emotional disturbances. Their treatment options include intensive outpatient and outpatient programs, which utilize evidence-based methods such as cognitive behavioral therapy and anger management. Additionally, the center offers outpatient treatment with methadone and buprenorphine. What truly distinguishes CenterPointe is its commitment to a personalized approach, customizing care to fit the unique needs of each client. With an emphasis on quality and tailored support, this facility serves both men and women who are looking for comprehensive rehabilitation services for addiction.

La Familia Counseling Service

La Familia Counseling Service

Oakland, CA

La Familia Counseling Service, situated in Oakland, CA, provides outpatient treatment for substance use issues as well as co-occurring disorders, catering to both adults and children. Utilizing evidence-based methods, the facility offers regular outpatient services that include anger management, brief interventions, and cognitive behavioral therapy. Specializing in programs designed for adolescents and those impacted by intimate partner violence, domestic violence, and sexual abuse, La Familia Counseling Service tailors its offerings to meet the diverse needs of individuals. The center ensures quality care for adults, children, adolescents, and young adults of all genders within a nurturing and supportive setting, addressing a broad spectrum of mental health concerns.

Gaudenzia Inc

Gaudenzia Inc

Philadelphia, PA

Gaudenzia Inc, situated in Philadelphia, PA, provides long-term residential treatment and transitional housing specifically designed for adult women facing substance use disorders. The facility offers tailored programs for those who have endured intimate partner violence, domestic violence, and sexual abuse. By emphasizing 12-step facilitation, anger management, and brief intervention techniques, Gaudenzia Inc delivers personalized care for both adult and senior women on their journey to recovery within a safe and nurturing setting. If you or someone you care about is seeking high-quality addiction treatment that prioritizes gender-specific needs, this facility is committed to empowering women to achieve lasting sobriety and improved overall wellness.

CBI Encompass Health Services

CBI Encompass Health Services

Littlefield, AZ

CBI Encompass Health Services, located in Littlefield, AZ, provides a wide range of rehabilitation programs designed for adults and seniors dealing with substance use disorders alongside co-occurring mental health challenges. The center offers several outpatient services, including intensive outpatient treatment and outpatient detoxification, all grounded in evidence-based practices like cognitive behavioral therapy and anger management. Additionally, the facility features specialized programs aimed at supporting individuals who have faced trauma, intimate partner violence, or who have had interactions with the criminal justice system. With a focus on gender-specific care, CBI Encompass Health Services tailors its support to meet the distinct needs of both men and women. Discover compassionate and effective care at CBI Encompass Health Services, where your journey towards recovery is a priority.

BHG Lansing Treatment Center

BHG Lansing Treatment Center

Lansing, MI

Situated in Lansing, MI, the BHG Lansing Treatment Center specializes in providing tailored substance use treatment programs for both adults and young adults. The center offers a range of services, including intensive outpatient treatment, general outpatient care, and specific outpatient options such as methadone/buprenorphine or naltrexone treatment. They employ evidence-based strategies like brief interventions, cognitive behavioral therapy, and contingency management with motivational incentives, allowing them to customize treatment plans according to individual needs. Additionally, BHG Lansing Treatment Center features distinctive programs designed specifically for active duty military personnel, as well as separate offerings for adult men and women. With a strong emphasis on quality care, the facility delivers comprehensive support to all clients on their journey to recovery from substance use disorders.

Breakthroughs Counseling and Recovery

Breakthroughs Counseling and Recovery

Jacksonville, FL

Located in Jacksonville, FL, Breakthroughs Counseling and Recovery specializes in a variety of evidence-based treatment programs aimed at addressing substance use and co-occurring mental health disorders for both adults and children. The center caters to specific groups, including criminal justice clients, veterans, and young adults, offering a range of services such as intensive outpatient care, outpatient programs, and standard outpatient services. Their treatment methods encompass strategies like 12-step facilitation, anger management, and brief interventions, all focused on providing personalized care for both male and female clients. With a strong dedication to delivering high-quality care and customized treatment plans, Breakthroughs stands out as a leading option for individuals in the Jacksonville area who are looking for comprehensive and effective rehabilitation services.

ESD113/True North Student Assistance

ESD113/True North Student Assistance

Olympia, WA

Situated in Olympia, WA, ESD113/True North Student Assistance is a holistic rehabilitation center that specializes in treating substance use and co-occurring mental health disorders for both adults and children. The center offers a range of treatment options, including intensive outpatient, outpatient, and regular outpatient programs. Employing evidence-based methods like cognitive behavioral therapy and motivational interviewing, it serves adolescents, individuals with dual diagnoses, and people of all genders. With a commitment to providing high-quality care and personalized treatment plans, this facility aims to help adults, children, and young adults attain lasting recovery and enhance their mental well-being.

Blue Mountain Counseling

Blue Mountain Counseling

Dayton, WA

Located in Dayton, WA, Blue Mountain Counseling provides a range of treatment options, including intensive outpatient, outpatient, and regular outpatient services for substance use and co-occurring mental health disorders for both adults and children. The facility employs various therapeutic methods such as brief intervention, cognitive behavioral therapy, and motivational interviewing, ensuring that care is customized to meet the unique needs of each client. Catering to adults and seniors of all genders, Blue Mountain Counseling is particularly known for its personalized approach to treatment. Committed to delivering high-quality care and adhering to evidence-based practices, this center has become a reliable resource for individuals seeking effective and individualized support for addiction in a welcoming environment.

Compass Health

Compass Health

Nevada, MO

Situated in Nevada, MO, Compass Health specializes in treating both substance use disorders and co-occurring mental health issues for individuals of all ages, including adults and children. The center offers a range of treatment options, such as intensive outpatient services, outpatient therapy, and medication-assisted therapies using methadone, buprenorphine, or naltrexone. Employing techniques like brief intervention, cognitive behavioral therapy, and motivational interviewing, Compass Health effectively addresses the unique needs of clients facing dual diagnoses. The facility serves adults and seniors across all genders, placing a strong emphasis on personalized care and evidence-based methods. Fully committed to delivering quality and comprehensive treatment, this center aims to support clients throughout their recovery journey.

Spindletop Center

Spindletop Center

Orange, TX

Located in Orange, TX, Spindletop Center delivers a wide range of rehabilitation services aimed at helping both adults and children who are facing substance use disorders along with co-occurring mental health challenges. The center offers various treatment options including intensive outpatient, outpatient, and regular outpatient programs. Their methodologies encompass techniques like 12-step facilitation, anger management, and brief intervention. Additionally, there are specialized programs designed for adolescents, adult women, and individuals dealing with both mental health and substance use issues. Prioritizing high-quality care and personalized treatment, Spindletop Center is committed to supporting clients on their journey to lasting recovery. The center warmly welcomes male and female clients, fostering a supportive and inclusive atmosphere for anyone seeking to overcome addiction.

Human Skills and Resources Inc

Human Skills and Resources Inc

Tulsa, OK

Human Skills and Resources Inc, located in Tulsa, OK, provides a wide array of addiction treatment services. Their offerings include detoxification and specialized substance use treatment through both intensive outpatient programs and outpatient detox. The center emphasizes approaches like anger management, cognitive behavioral therapy, and the Matrix Model, ensuring that the treatment is customized to meet the unique needs of each individual. Additionally, they have special programs designed for adult men, adult women, and those who have faced trauma. Catering to adults and young adults across all genders, this facility is dedicated to providing high-quality care to support individuals on their paths to recovery.

Alternative Drug and Alcohol

Alternative Drug and Alcohol

Cumberland, MD

Situated in Cumberland, MD, the Alternative Drug and Alcohol center provides a thorough range of substance use treatment options for both adults and seniors. Their unique programs are designed specifically for adult men and women, along with clients involved in the criminal justice system. Emphasizing intensive outpatient treatment as well as outpatient and regular outpatient care, this facility employs various strategies such as anger management, brief intervention, and relapse prevention. With gender-specific programs, they ensure that care is tailored to the needs of both male and female clients. Renowned for their high quality of care and personalized treatment plans, Alternative Drug and Alcohol stands out as a reliable choice for individuals seeking effective addiction rehabilitation services.

Capricorn Health LLC

Capricorn Health LLC

Elkton, MD

Located in Elkton, MD, Capricorn Health LLC provides a full range of substance use treatment options, including outpatient care, as well as methadone/buprenorphine and naltrexone programs. This center is dedicated to counseling for substance use disorders and also offers convenient telemedicine and telehealth therapy sessions. With an emphasis on personalized care, Capricorn Health LLC serves adults and young adults from all genders. The facility is committed to delivering high-quality treatment and customizes care plans to address the specific needs of every individual. If you or someone you care about is in need of compassionate and effective support for addiction, take a look at the specialized services available at Capricorn Health LLC.

About Depression Treatment

Depression and substance use often occur together, with each condition potentially worsening the other. At Penn Spine and Rehab, we help individuals find treatment programs that address both depression and addiction simultaneously for the best possible outcomes.

The Connection Between Depression and Addiction

Many people with depression turn to alcohol or drugs to cope with painful feelings, while substance use itself can cause or worsen depressive symptoms. This complex relationship requires integrated treatment that addresses both conditions.

Signs of co-occurring depression and substance use include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Loss of interest in previously enjoyed activities
  • Using substances to cope with difficult emotions
  • Worsening depression despite substance use
  • Difficulty functioning at work, school, or in relationships

Integrated Treatment Approaches

Dual diagnosis treatment programs offer comprehensive care including:

Finding the Right Program

Look for treatment centers with psychiatrists and mental health professionals on staff, not just addiction counselors. Residential programs often provide the intensive support needed to stabilize both conditions, while ongoing outpatient care maintains progress.

Causes & Risk Factors for Depression

Depression develops through a combination of genetic, environmental, and psychological factors. Understanding these risk factors can help identify who may be vulnerable and support early intervention.

  • Neurochemical overlap — both depression and addiction involve serotonin and dopamine dysregulation
  • Self-medication — using substances to numb emotional pain, hopelessness, or fatigue
  • Substance-induced depression — chronic alcohol or drug use depletes mood-regulating neurotransmitters
  • Genetic predisposition — shared hereditary risk factors for both conditions
  • Childhood trauma and adverse experiences
  • Chronic stress, grief, loss, or major life changes
  • Social isolation — both depression and addiction worsen with loneliness

Depression Statistics

21M

US adults had at least one major depressive episode in 2021

Source: NIMH

33%

Of people with major depression also have a substance use disorder

Source: JAMA

63%

Of people with alcohol dependence have a history of depression

Source: NIAAA

2x

People with depression are twice as likely to develop addiction

Source: NIDA

48K+

Suicides in the US in 2021 — substance use is a major risk factor

Source: CDC

40%

Improvement in addiction outcomes when depression is treated concurrently

Source: SAMHSA

What to Expect in Depression Treatment

1

Comprehensive Assessment (Days 1-3)

Psychiatric evaluation and substance use assessment. PHQ-9 depression screening. Determine if depression is independent or substance-induced. Create integrated treatment plan.

2

Detox & Psychiatric Stabilization (Days 3-10)

Safe withdrawal management. Begin antidepressant medication if indicated (SSRIs may take 2-4 weeks for full effect). Monitor suicidal ideation. Comfort care and sleep hygiene.

3

Active Integrated Treatment (Weeks 2-8)

CBT targeting both depressive thinking patterns and addiction triggers. Behavioral activation to counter depression-related withdrawal. Group therapy. Medication optimization.

4

Skill Building & Recovery Planning (Weeks 8-12)

Relapse prevention for both conditions. Healthy routine development (exercise, sleep, nutrition). Family therapy. Building social support network beyond substances.

5

Aftercare & Maintenance (Ongoing)

Continued antidepressant management with psychiatrist. Step-down to outpatient therapy. Peer support groups. Ongoing monitoring of mood and cravings. Safety planning.

Frequently Asked Questions About Depression Treatment

Resources & Sources

The information on this page is based on peer-reviewed research and authoritative health organizations. Always consult a healthcare professional for medical advice.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always seek the guidance of a qualified healthcare provider for diagnosis and treatment. If you or someone you know is in crisis, call 911 or the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7).

Depression & Addiction Treatment | Penn Spine and Rehab